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Literature summary for 3.4.21.69 extracted from

  • D'Ursi, P.; Orro, A.; Morra, G.; Moscatelli, M.; Trombetti, G.; Milanesi, L.; Rovida, E.
    Molecular dynamics and docking simulation of a natural variant of Activated Protein C with impaired protease activity: implications for integrin-mediated antiseptic function (2015), J. Biomol. Struct. Dyn., 33, 85-92.
    View publication on PubMed

Application

Application Comment Organism
medicine possible therapeutic applications of the enzyme mutant G216D, that has no catalytic activity but retains its antiseptic function without anticoagulant side effects Homo sapiens

Protein Variants

Protein Variants Comment Organism
G216D a naturally occuring mutation, the mutant shows impaired protease activity, while preserving the overall protein fold. Superposition of the integrin binding motifs in wild-type and mutant forms suggests that the interaction with integrin can still occur and thus the mutant is likely to retain its antiseptic function related to the neutrophyl integrin binding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Synonyms

Synonyms Comment Organism
Activated protein C
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Homo sapiens
APC
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Homo sapiens

General Information

General Information Comment Organism
malfunction naturally occuring mutation G216D in the specificity pocket of the enzyme causes protein C deficiency. Superposition of the integrin binding motifs in wild-type and mutant forms suggests that the interaction with integrin can still occur and thus the mutant is likely to retain its antiseptic function related to the neutrophyl integrin binding Homo sapiens
additional information molecular model of the complex of APC with alphaVbeta3 integrin obtained by protein-protein docking approach, molecular dynamics and docking simulation of natural mutant G216D of activated protein C with impaired protease activity, implications for integrin-mediated antiseptic function, overview Homo sapiens
physiological function the enzyme has anticoagulant function in the coagulation system counteracting apoptosis and inflammation in cells. the antiseptic activity of the enzyme is mediated by its binding to leukkocyte integrins, the integrin-binding motif of the enzyme locates at the N-terminus of the catalytic chain Homo sapiens