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Literature summary for 3.4.21.69 extracted from

  • Lichtnekert, J.; Rupanagudi, K.V.; Kulkarni, O.P.; Darisipudi, M.N.; Allam, R.; Anders, H.J.
    Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in MRL-Fas(lpr) mice (2011), J. Immunol., 187, 3413-3421.
    View publication on PubMed
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Application

Application Comment Organism
medicine activated protein C is a natural protein with anticoagulant and immunomodulatory effects, and its recombinant version is approved by the U.S. Food and Drug Administration to treat severe sepsis Homo sapiens
pharmacology activated protein C is a natural protein with anticoagulant and immunomodulatory effects, and its recombinant version is approved by the U.S. Food and Drug Administration to treat severe sepsis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
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Synonyms

Synonyms Comment Organism
Activated protein C
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 Homo sapiens
APC
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 Homo sapiens

General Information

General Information Comment Organism
physiological function treatment with recombinant activated protein C reduces the activation of splenic dendritic cells as well as systemic inflammation in MRL-Fas(lpr) mice. Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in autoimmune female MRL-Fas(lpr) mice injected with recombinant human activated protein C, overview. Activated protein C treatment significantly suppresses lupus nephritis as evidenced by decrease in activity index, glomerular IgG and complement C3 deposits, macrophage counts, as well as intrarenal IL-12 expression. Further, activated protein C attenuates cutaneous lupus and lung disease as compared with vehicle-treated MRL-Fas(lpr) mice. In addition, parameters of systemic autoimmunity, such as plasma cytokine levels of IL-12p40, IL-6, and CCL2/MCP-1, and numbers of B cells and plasma cells in spleen are suppressed by activated protein C Homo sapiens