Application | Comment | Organism |
---|---|---|
pharmacology | activated protein C is approved by the Food and Drug Administration as drug for severe sepsis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a thrombin derivative containing the Gla-domain of APC recapitulates all protective effects of APC with a 20 to 50fold higher efficacy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated protein C inhibits high mobility group box 1 signaling in endothelial cells, protective effects of APC are mediated through endothelial cell protein C receptor and protease-activated receptor 1, PAR-1. APC potently inhibits the release of HMGB1, downregulates the expression of HMGB1 receptors, and downregulates the adhesion of the monocytic cell line, THP-1, to HMGB1-activated endothelial cells, and it also down-regulates the cell surface expression of all 3 HMGB1 receptors in endothelial cells | Homo sapiens |