Activating Compound | Comment | Organism | Structure |
---|---|---|---|
protein S | the cofactor function of protein S is weak in purified systems, only enhancing the rate of APC inactivation of factor Va twofold as compared with the inactivation of the cofactor by APC alone | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | Homo sapiens | activated protein C inactivates membrane-bound factor Va following cleavages of the heavy chain at Arg306, Arg506, and Arg679. In the absence of the APC-cleavage sites at Arg306 and Arg506, the active cofactor is unable to be significantly inactivated by APC in the presence of a membrane surface | ? | - |
? | |
Factor VIIIa + H2O | Homo sapiens | APC cleaves factor VIIIa at two peptide bonds, Arg336 and Arg562 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | activated protein C inactivates membrane-bound factor Va following cleavages of the heavy chain at Arg306, Arg506, and Arg679. In the absence of the APC-cleavage sites at Arg306 and Arg506, the active cofactor is unable to be significantly inactivated by APC in the presence of a membrane surface | Homo sapiens | ? | - |
? | |
Factor Va + H2O | activated protein C inactivates membrane-bound factor Va following cleavages of the heavy chain at Arg306, Arg506, and Arg679. It is the first cleavage at Arg306 that is the inactivating cleavage. Cleavage at Arg306 leads to full loss of cofactor function and the dissociation of the A2 domain from the rest of the molecule. Complete inactivation of factor Va by APC requires the presence of a membrane surface, however, factor Va can be cleaved by APC in the absence of a membrane surface at Arg506 and Arg679, retaining approximately 80% of its cofactor activity | Homo sapiens | ? | - |
? | |
Factor VIIIa + H2O | APC cleaves factor VIIIa at two peptide bonds, Arg336 and Arg562 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated protein C and its cofactor, protein S in the presence of a membrane surface cleaves and inactivates the cofactors of the intrinsic and prothrombinase complexes, factor VIIIa and factor Va, respectively | Homo sapiens |