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Literature summary for 3.4.21.69 extracted from

  • Barhoover, M.A.; Kalafatis, M.
    Cleavage at both Arg306 and Arg506 is required and sufficient for timely and efficient inactivation of factor Va by activated protein C (2011), Blood Coagul. Fibrinolysis, 22, 317-324.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
protein S the cofactor function of protein S is weak in purified systems, only enhancing the rate of APC inactivation of factor Va twofold as compared with the inactivation of the cofactor by APC alone Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor Va + H2O Homo sapiens activated protein C inactivates membrane-bound factor Va following cleavages of the heavy chain at Arg306, Arg506, and Arg679. In the absence of the APC-cleavage sites at Arg306 and Arg506, the active cofactor is unable to be significantly inactivated by APC in the presence of a membrane surface ?
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?
Factor VIIIa + H2O Homo sapiens APC cleaves factor VIIIa at two peptide bonds, Arg336 and Arg562 ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor Va + H2O activated protein C inactivates membrane-bound factor Va following cleavages of the heavy chain at Arg306, Arg506, and Arg679. In the absence of the APC-cleavage sites at Arg306 and Arg506, the active cofactor is unable to be significantly inactivated by APC in the presence of a membrane surface Homo sapiens ?
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?
Factor Va + H2O activated protein C inactivates membrane-bound factor Va following cleavages of the heavy chain at Arg306, Arg506, and Arg679. It is the first cleavage at Arg306 that is the inactivating cleavage. Cleavage at Arg306 leads to full loss of cofactor function and the dissociation of the A2 domain from the rest of the molecule. Complete inactivation of factor Va by APC requires the presence of a membrane surface, however, factor Va can be cleaved by APC in the absence of a membrane surface at Arg506 and Arg679, retaining approximately 80% of its cofactor activity Homo sapiens ?
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?
Factor VIIIa + H2O APC cleaves factor VIIIa at two peptide bonds, Arg336 and Arg562 Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
Activated protein C
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Homo sapiens
APC
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Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C and its cofactor, protein S in the presence of a membrane surface cleaves and inactivates the cofactors of the intrinsic and prothrombinase complexes, factor VIIIa and factor Va, respectively Homo sapiens