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Literature summary for 3.4.21.69 extracted from
- Role of activated protein C and its receptor in inhibition of tumor metastasis (2009), Blood, 113, 3371-3374.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | important role for the aPC/endothelial protein C receptor pathway in reducing metastasis via inhibition of tumor cell adhesion and transmigration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | pretreatment of endothelial monolayers with recombinant activated protein C concentrations (10-25 nmol) leads to significantly decreased adhesion of B16-F10 melanoma cells. A 44% reduction in lung metastases in recombinant activated protein C-treated compared with control mice. Recombinant activated protein C markedly decreases tumor cell entrapment within the liver of mice | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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