Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.69 extracted from

  • Griffin, J.H.; Fernandez, J.A.; Gale, A.J.; Mosnier, L.O.
    Activated protein C (2007), J. Thromb. Haemost., 5 Suppl 1, 73-80.
    View publication on PubMed
Search for more literature for 3.4.21.69

Cloned(Commentary)

Cloned (Comment) Organism
gene PROC, location on chromosome 1p13-14 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockout mice show perinatal lethality, reduced enzyme levels permit birth and growth but lead to thrombosis and inflammation with an early onset Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
active factor Va + H2O Homo sapiens proteolytic inactivation inactive factor V + ?
-
 ?
active factor VIIIa + H2O Homo sapiens proteolytic inactivation inactive factor VIII + domain B
-
 ?
additional information Homo sapiens the enzyme has anticoagulant, antiapoptotic, and cytoprotective activities, mechanisms, overview, severe homozygous enzyme-deficiency causes massive, usually lethal thrombotic complications that arise in infants, heterozygous adults show a risk for venous thrombosis ?
-
 ?
additional information Mus musculus the enzyme has anticoagulant, antiapoptotic, and cytoprotective activities, murine injury models, mechanisms, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene PROC
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation of residues 97, 248, 313, and 329 Homo sapiens
proteolytic modification proteolytic cleavage and activation by thrombin at Arg169 removing the activation peptide, thrombomodulin and endothelial cell protein C receptor PAR-1 are required for efficient enzyme activation Homo sapiens
proteolytic modification proteolytic cleavage and activation by thrombin removing the activation peptide, thrombomodulin and endothelial cell protein C receptor PAR-1 are required for efficient enzyme activation Mus musculus
side-chain modification beta-hydroxylation of Asp71, and carboxylation of nine glutamic acid residues in the N-terminus Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
degradation of blood coagulation factors Va and VIIIa the catalytic triad is formed by His211, Asp257, and Ser360 Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
active factor Va + H2O proteolytic inactivation Homo sapiens inactive factor V + ?
-
 ?
active factor VIIIa + H2O proteolytic inactivation Homo sapiens inactive factor VIII + domain B
-
 ?
additional information the enzyme has anticoagulant, antiapoptotic, and cytoprotective activities, mechanisms, overview, severe homozygous enzyme-deficiency causes massive, usually lethal thrombotic complications that arise in infants, heterozygous adults show a risk for venous thrombosis Homo sapiens ?
-
 ?
additional information the enzyme has anticoagulant, antiapoptotic, and cytoprotective activities, murine injury models, mechanisms, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More the enzyme contains the N-terminal Gladomain, residues 1-37, two epidermal growth factor-like regions, residues 46-92 and 93-136, an activation peptide, residues 158-169, and the serine protease domain, residue 170-419 Homo sapiens

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Mus musculus
Activated protein C
-
 Homo sapiens
APC
-
 Mus musculus
APC
-
 Homo sapiens