Inhibitors | Comment | Organism | Structure |
---|---|---|---|
prothrombin | addition results in a 10fold decreased inactivation rate in absence and 4fold in presence of protein S, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics with wild-type and mutant factors Va | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
active factor Va + H2O | Homo sapiens | proteolytic inactivation | inactive factor V heavy chain + peptide fragment 307-709 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
active factor Va + H2O | proteolytic inactivation | Homo sapiens | inactive factor V heavy chain + peptide fragment 307-709 | - |
? | |
active factor Va + H2O | proteolytic inactivation, cleavage at Arg306 and Arg506 | Homo sapiens | inactive factor V heavy chain + peptide fragment 307-709 | - |
? | |
active factor Va mutant R306Q + H2O | proteolytic inactivation, cleavage at Arg506 | Homo sapiens | ? | - |
? | |
active factor Va mutant R506Q + H2O | proteolytic inactivation, cleavage at Arg306 | Homo sapiens | ? | - |
? | |
S2366 + H2O | a chromogenic substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
protein S | stimulates, partially prevents the inhibition of the enzyme by prothrombin | Homo sapiens |