Literature summary for 3.4.21.69 extracted from

Yang, L.; Manithody, C.; Rezaie, A.R.
The functional significance of the autolysis loop in protein C and activated protein C (2005), Thromb. Haemost., 94, 60-68.

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Protein Variants

Protein Variants	Comment	Organism
additional information	replacement of autolysis loop of protein by the corresponding loop of factor X. Mutant is activated by thrombin with 5fold higher rate in presence of Ca2+, Ca2+-affinity of mutant is impaired 3fold and anticoagulation function of mutant is improved 4-5fold in the absence, but not in the presence of protein S. Plasma half-life of mutant is markedly shortened	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)