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Literature summary for 3.4.21.69 extracted from
- Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa (2006), Biochem. J., 396, 355-362.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000102 | - |
Factor VIIIa | pH 7.2, 37°C, cleavage at Arg336 in A1 subunit | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor VIIIa + H2O | proteolytic inactivation by cleavage at Arg336 in A1 subunit and Arg562 in A2 subunit. Cleavage at A1 site is the dominant mechanism for factor VIIIa inactivation | Homo sapiens | ? | - |
? |  |
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