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Literature summary for 3.4.21.69 extracted from

  • Schmidt, A.E.; Padmanabhan, K.; Underwood, M.C.; Bode, W.; Mather, T.; Bajaj, S.P.
    Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops (2002), J. Biol. Chem., 277, 28987-28995.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.39
-
 S-2288 pH 7.4, 37°C, 100 mM NaCl Homo sapiens
0.409
-
 S-2288 pH 7.4, 37°C, 150 mM NaCl Homo sapiens
0.433
-
 S-2288 pH 7.4, 37°C, 200 mM NaCl Homo sapiens
0.683
-
 S-2288 pH 7.4, 37°C, 20 mM NaCl Homo sapiens
0.741
-
 S-2288 pH 7.4, 37°C, 50 mM NaCl Homo sapiens
0.802
-
 S-2288 pH 7.4, 37°C, 10 mM NaCl Homo sapiens
1.606
-
 S-2288 pH 7.4, 37°C, 4 mM NaCl Homo sapiens
1.723
-
 S-2288 pH 7.4, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Na+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-2288 + H2O i.e. D-Ile-L-Pro-L-Arg-p-nitroanilide Homo sapiens ?
-
 ?