Cloned (Comment) | Organism |
---|---|
APCTPTGla chimera, much more potent anticoagulant than wild-type APC in plasma | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | Homo sapiens | protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a | ? | - |
? | |
Factor VIIIa + H2O | Homo sapiens | protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | cleaves rapidly at Arg506 and slowly at Arg 306 | Homo sapiens | ? | - |
? | |
Factor Va + H2O | protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a | Homo sapiens | ? | - |
? | |
factor Va Leiden + H2O | - |
Homo sapiens | ? | - |
? | |
Factor VIIIa + H2O | - |
Homo sapiens | ? | - |
? | |
Factor VIIIa + H2O | protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a | Homo sapiens | ? | - |
? |