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Literature summary for 3.4.21.69 extracted from

  • Yegneswaran, S.; Smirnov, M.D.; Safa, O.; Esmon, N.L.; Esmon, C.T.; Johnson, A.E.
    Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study (1999), J. Biol. Chem., 274, 5462-5468.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
APCTPTGla chimera, much more potent anticoagulant than wild-type APC in plasma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor Va + H2O Homo sapiens protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a ?
-
?
Factor VIIIa + H2O Homo sapiens protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor Va + H2O cleaves rapidly at Arg506 and slowly at Arg 306 Homo sapiens ?
-
?
Factor Va + H2O protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a Homo sapiens ?
-
?
factor Va Leiden + H2O
-
Homo sapiens ?
-
?
Factor VIIIa + H2O
-
Homo sapiens ?
-
?
Factor VIIIa + H2O protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a Homo sapiens ?
-
?