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Literature summary for 3.4.21.69 extracted from
- Specificity of activated human protein C (1985), Biochem. J., 230, 497-502.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-Amino-D-Phe-Pro-Arg-CH2Cl | - |
Homo sapiens |  |
| Ala-Phe-Arg-CH2Cl | - |
Homo sapiens | |
| D-Phe-Pro-Arg-CH2Cl | - |
Homo sapiens | |
| D-Tyr-Pro-Arg-CH2Cl | - |
Homo sapiens | |
| I2-D-Phe-Pro-Arg-CH2Cl | - |
Homo sapiens | |
| Ile-Leu-Arg-CH2Cl | - |
Homo sapiens | |
| Ile-Pro-Arg-CH2Cl | - |
Homo sapiens | |
| Phe-Ala-Arg-CH2Cl | - |
Homo sapiens | |
| Phe-Phe-Arg-CH2Cl | - |
Homo sapiens | |
| Tyr-Phe-Arg-CH2Cl | - |
Homo sapiens | |
| Val-Val-Arg-CH2Cl | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.116 | - |
Toluene-p-sulfonyl-Gly-Pro-Lys | - |
Homo sapiens | |
| 0.259 | - |
D-Val-cyclohexyl-Ala-Arg | - |
Homo sapiens | |
| 0.345 | - |
D-Val-Leu-Arg | - |
Homo sapiens | |
| 0.373 | - |
D-Phe-pipecolyl-Arg | - |
Homo sapiens | |
| 0.505 | - |
D-Pro-Phe-Arg | - |
Homo sapiens | |
| 0.528 | - |
Benzyloxycarbonyl-Val-Gly-Arg | - |
Homo sapiens | |
| 0.606 | - |
D-Ile-Pro-Arg | - |
Homo sapiens | |
| 0.762 | - |
Toluene-p-sulfonyl-Gly-Pro-Arg | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Benzyloxycarbonyl-Val-Gly-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| D-Ile-Pro-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| D-Phe-pipecolyl-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| D-Pro-Phe-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| D-Val-cyclohexyl-Ala-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| D-Val-Leu-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | the enzyme is able to accomodate large hydrophobic residues such as phenylalanine and leucine in the P2 position. In the P3 position, the enzyme prefers an apolar D-amino acid residue | Homo sapiens | ? | - |
? | |
| additional information | specificity: substrates with arginine in the P1 position have the highest activity | Homo sapiens | ? | - |
? | |
| Toluene-p-sulfonyl-Gly-Pro-Arg + H2O | - |
Homo sapiens | ? | - |
? | |
| Toluene-p-sulfonyl-Gly-Pro-Lys + H2O | - |
Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.38 | - |
Benzyloxycarbonyl-Val-Gly-Arg | - |
Homo sapiens | |
| 0.81 | - |
Toluene-p-sulfonyl-Gly-Pro-Lys | - |
Homo sapiens | |
| 1.9 | - |
D-Val-cyclohexyl-Ala-Arg | - |
Homo sapiens | |
| 31 | - |
D-Pro-Phe-Arg | - |
Homo sapiens | |
| 35 | - |
D-Val-Leu-Arg | - |
Homo sapiens | |
| 53 | - |
D-Phe-pipecolyl-Arg | - |
Homo sapiens | |
| 87 | - |
Toluene-p-sulfonyl-Gly-Pro-Arg | - |
Homo sapiens | |
| 200 | - |
D-Ile-Pro-Arg | - |
Homo sapiens | |
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