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Literature summary for 3.4.21.68 extracted from

  • Bu, C.; Gao, L.; Xie, W.; Zhang, J.; He, Y.; Cai, G.; McCrae, K.R.
    beta2-glycoprotein i is a cofactor for tissue plasminogen activator-mediated plasminogen activation (2009), Arthritis Rheum., 60, 559-568.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information neither human albumin nor control human IgG affect tPA-dependent plasminogen activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information stimulation of tPA-mediated plasminogen activity by beta2-glycoprotein I is inhibited by monoclonal anti-beta2GPI antibodies as well as by anti-beta2GPI antibodies from patients with antiphospholipid syndrome. Binding to beta2-glycoprotein I is competitively inhibited by fluid-phase tPA Homo sapiens
NaCl high concentrations inhibit the binding of beta2-glycoprotein I to tPA Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000464
-
 plasminogen in the presence of beta2-glycoprotein I Homo sapiens
0.0003148
-
 plasminogen in the presence of beta2-glycoprotein I domain V Homo sapiens
0.0004538
-
 plasminogen in the presence of bovine serum albumin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Glu-plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
glutaryl-Gly-7-Arg-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Homo sapiens
tPA
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1149
-
 plasminogen in the presence of bovine serum albumin Homo sapiens
0.231
-
 plasminogen in the presence of beta2-glycoprotein I Homo sapiens
0.4718
-
 plasminogen in the presence of beta2-glycoprotein I domain V Homo sapiens

Cofactor

Cofactor Comment Organism Structure
additional information native and recombinant beta2-glycoprotein I or its domain V stimulate tPA-dependent plasminogen activation in a concentration-dependent manner. Beta2-glycoprotein I binds tPA with high affinity (Kd =20 nmol), stimulates tPA amidolytic activity, and causes an overall 20fold increase in the catalytic efficiency (kcat/Km) of tPA-mediated conversion of Glu-plasminogen to plasmin Homo sapiens