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Literature summary for 3.4.21.60 extracted from

  • Walker, F.J.; Owen, W.G.; Esmon, C.T.
    Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom) (1980), Biochemistry, 19, 1020-1023.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Phospholipid stimulates activation of both prothrombin and prethrombin 2, activation of prethrombin 1 is insensitive Oxyuranus scutellatus
Prothrombin fragment 2 stimulates activation of prethrombin 2 Oxyuranus scutellatus

Inhibitors

Inhibitors Comment Organism Structure
benzamidine inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide Oxyuranus scutellatus
Bovine pancreas trypsin inhibitor inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide Oxyuranus scutellatus
Inhibitor present in the venom of Oxyuranus scutellatus inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide Oxyuranus scutellatus
additional information hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4nitroanilide is insensitive to: diisopropyl fluorophosphate, antithrombin III, chicken ovomucoid trypsin inhibitor, EDTA, 1,10-phenanthroline, activated protein C Oxyuranus scutellatus
NaCl inhibits activation of prethrombin 2, no effect on reaction with meizothrombin Oxyuranus scutellatus
Nalpha-p-toluenesulfonyl-L-Arg methyl ester inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide Oxyuranus scutellatus
Soybean trypsin inhibitor inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide Oxyuranus scutellatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Oxyuranus scutellatus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Oxyuranus scutellatus
-
Taipan snake
-
Oxyuranus scutellatus
-
scutellatus
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Oxyuranus scutellatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide + H2O
-
Oxyuranus scutellatus benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline
-
?
Meizothrombin + H2O des fragment 1 Oxyuranus scutellatus ?
-
?
additional information no hydrolysis of: benzoyl-Phe-Arg 4-nitroanilide, D-Val-Leu-Lys 4-nitroanilide Oxyuranus scutellatus ?
-
?
Prethrombin 1 + H2O
-
Oxyuranus scutellatus ?
-
?
Prethrombin 2 + H2O
-
Oxyuranus scutellatus ?
-
?
prothrombin + H2O
-
Oxyuranus scutellatus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8 hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide Oxyuranus scutellatus