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Literature summary for 3.4.21.6 extracted from

  • Jesty, J.; Nemerson, Y.
    The activation of bovine coagulation factor X (1976), Methods Enzymol., 45, 95-107.
    View publication on PubMed
Search for more literature for 3.4.21.6

Activating Compound

Activating Compound Comment Organism Structure
Factor V factor Xa forms the prothrombin-converting complex with factor V, phospholipid and Ca2+ Bos taurus
Phospholipid factor Xa forms the prothrombin-converting complex with factor V, phospholipid and Ca2+ Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ factor Xa forms the prothrombin-converting complex with factor V, phospholipid and Ca2+ Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Bos taurus major role is the activation of prothrombin ?
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 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification factor X is the zymogen Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chymotrypsin + H2O poor substrate Bos taurus ?
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 ?
factor VII + H2O cleavage of two bonds, rapid cleavage of an Arg-Ile bond and slower cleavage of an Y-Gly bond Bos taurus ?
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 ?
factor X + H2O cleavage of three bonds Bos taurus ?
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 ?
prothrombin + H2O cleaves first an Arg-Thr bond and then an Arg-Ile bond to form the two-chain enzyme Bos taurus thrombin + ?
-
 ?
prothrombin + H2O major role is the activation of prothrombin Bos taurus ?
-
 ?