Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
trhombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retinal pigment epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | trhombin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
FXa | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the gene expression of factor X in retinal pigment epithelial cells is decreased by blood serum, activated factor X, thrombin, transforming growth factor beta1, and platelet-derived growth factor | down |
Homo sapiens | the gene expression of factor X in retinal pigment epithelial cells is increased by hypoxia and prostaglandin E2 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | activated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial (RPE) cells. FXa induced chemotaxis of RPE cells via activation of the p38 mitogen-activated protein kinase signal transduction pathway. FXa also induces expression of vascular endothelial growth factor, heparin-binding epidermal growth factor-like growth factor, and basic fibroblast growth factor, as well as release of these factors from RPE cells | Homo sapiens |