Literature summary for 3.4.21.6 extracted from

Griffiths, A.E.; Wintermute, J.; Newell-Caito, J.L.; Fay, P.J.
Residues flanking scissile bonds in Factor VIII modulate rates of cleavage and proteolytic activation catalyzed by Factor Xa (2013), Biochemistry, 52, 8060-8068.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
factor VIII + H2O	Homo sapiens	factor Xa proteolytically activates Factor VIII by cleaving P1 residues Arg372, Arg740, and Arg1689. Factor Xa also catalyzes inactivating cleavages that occur on a slower time scale than the activating ones	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
factor VIII + H2O	factor Xa proteolytically activates Factor VIII by cleaving P1 residues Arg372, Arg740, and Arg1689. Factor Xa also catalyzes inactivating cleavages that occur on a slower time scale than the activating ones	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
factor Xa	-	Homo sapiens
FXa	-	Homo sapiens

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Release 2023.1 (January 2023)