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Literature summary for 3.4.21.6 extracted from
- Modulation of prothrombinase assembly and activity by phosphatidylethanolamine (2011), J. Biol. Chem., 286, 35535-35542.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | activates prothrombinase activity after enzyme binding to membranes, binding to model membranes, binding of prothrombinase via factor Va, overview. 1,2-diphytanoyl-sn-glycero-3-phosphocholine deminishes activation by 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | Bos taurus |  |
| 1,2-dioleoyl-sn-glycero-3-phosphoserine | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prothrombinase | - |
Bos taurus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | constituents of platelet membranes regulate the activity of the prothrombinase complex. Membranes containing phosphatidylcholine and phosphatidylethanolamine bind factor Va with high affinity in the absence of phosphatidylserine, specific protein-PE interactions appear to contribute to the effects of phosphatidylethanolamine | Bos taurus |
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