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Literature summary for 3.4.21.6 extracted from

  • Borensztajn, K.; Peppelenbosch, M.P.; Spek, C.A.
    Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation (2010), Thromb. Res., 125, e323-e328.
    View publication on PubMed
Search for more literature for 3.4.21.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens coagulation factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation through induction of myosin light chain phosphorylation and LIMK1 activation, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information coagulation factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation through induction of myosin light chain phosphorylation and LIMK1 activation, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function factor Xa plays a role in blood coagulation. And FXa also plays a key role in cell migration, and is involved in a mechanism of PAR-1-mediated inhibition of migration via Rho and Src dependent pathways Homo sapiens