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Literature summary for 3.4.21.6 extracted from

  • Imberti, D.; DallAsta, C.; Pierfranceschi, M.G.
    Oral factor Xa inhibitors for thromboprophylaxis in major orthopedic surgery: a review (2009), Intern. Emerg. Med., 4, 471-477.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
apixaban i.e. BMS-562247, a small molecule able to inhibit in a selective and reversible manner the active site of both free and prothrombinase-bound factor Xa, requires oraladministration, bleeding rates of 0.69% Homo sapiens
DX9065a requires system administration Homo sapiens
LY517717 a direct factor Xa inhibitor, requires oraladministration, with an oral bioavailability of 25-82%. LY517717 is apparently primarily cleared via a gastrointestinal route Homo sapiens
additional information clinical studies, efficacy and safety of factor Xa inhibitors, overview Homo sapiens
otamixaban requires system administration Homo sapiens
rivaroxaban i.e. BAY 59-7939, requires oraladministration. It is absorbed in the gastrointestinal tract, is primarily excreted by the kidneys, and has a bioavailability of more than 80%, and bleeding rates of 4.3-10.2% Homo sapiens
YM150 a direct inhibitor of factor Xa, requires oraladministration,bleeding rate is 11.8-23.5% Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens