Literature summary for 3.4.21.6 extracted from

Wang, L.; Zhang, D.; Raghavan, N.; Yao, M.; Ma, L.; Frost, C.E.; Frost, C.A.; Maxwell, B.D.; Chen, S.Y.; He, K.; Goosen, T.C.; Humphreys, W.G.; Grossman, S.J.
In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies (2010), Drug Metab. Dispos., 38, 448-458.

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Inhibitors

Inhibitors	Comment	Organism	Structure
apixaban	an oral, direct, and highly selective factor Xa inhibitor in late-stage clinical development for the prevention and treatment of thromboembolic diseases. Evaluation of the metabolic drug-drug interaction potential of apixaban in vitro, overview. Apixaban shows a slow metabolic turnover in incubations of human liver microsomes with formation of O-demethylation and hydroxylation products as prominent in vitro metabolites	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary	Homo sapiens	-
liver	-	Homo sapiens	-

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Release 2023.1 (January 2023)