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Literature summary for 3.4.21.6 extracted from
- The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase (2008), Thromb. Haemost., 99, 511-522.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the presence of prothrombin-derived fragment 1 accelerates both the rate of cleavage at residues R320 of prethrombin 1 and thrombin formation by prothrombinase | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hir54-65(SO3+) | C-terminal fragment of hirudin. Inhibition of the rate of cleavage at residues R320 of prethrombin 2, thrombin formation, and the activation of prethrombin 2 by prothrombinase | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prethrombin 1 + H2O | activation of prethrombin 1 is slow with cleavages at residues R320 and R271 occuring with similar rates | Homo sapiens | thrombin + ? | - |
? | |
| Prethrombin 2 + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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