Literature summary for 3.4.21.6 extracted from

Wong, P.C.; Watson, C.A.; Crain, E.J.
Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits (2008), J. Thromb. Haemost., 6, 1736-1741.

Search for more literature for 3.4.21.6

Application

Application	Comment	Organism
pharmacology	study on use of apixaban for prevention of arterial thrombosis in rabbit models of electrically induced carotid artery thrombosis and cuticle bleeding time. Addition of aspirin to apixaban significally reduces the thrombus weight with no significant increase in bleeding time. Addition of aspirin and apixaban to clopidogrel produces a further significant reduction in thrombus weight. Combination of clopidogrel and aspirin with apixaban produces a significant but moderate 2.1fold increase in bleeding time	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
apixaban	study on use for prevention of arterial thrombosis in rabbit models of electrically induced carotid artery thrombosis and cuticle bleeding time. Addition of aspirin to apixaban significally reduces the thrombus weight with no significant increase in bleeding time. Addition of aspirin and apixaban to clopidogrel produces a further significant reduction in thrombus weight. Combination of clopidogrel and aspirin with apixaban produces a significant but moderate 2.1fold increase in bleeding time	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)