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Literature summary for 3.4.21.6 extracted from
- Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa (2008), J. Biol. Chem., 283, 29770-29783.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| protein Z-dependent protease inhibitor | inhibition by branched pathway acyl-intermediate trapping mechanism. Reaction proceeds by the initial assembly of a membrane-associated protein Z-protein Z-dependent protease inhibitor-factor Xa Michaelis complex followed by conversion to a stable protein Z-dependent protease inhibitor-factor Xa complex. Assembly of the Michaelis complex is rate-limiting. For every factor Xa molecule inhibited, two inhibitor molecules are cleaved. Protein Z dissociates from protein Z-dependent inhibitor once a stable complex with factor Xa is formed. It acts catalytically to accelerate the membrane-dependent protein Z-dependent protease-factor Xa reaction | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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