Literature summary for 3.4.21.6 extracted from

Fiore, M.M.; Mackie, I.J.
Dual effect of platelet factor 4 on the activities of factor Xa (2009), Biochem. Biophys. Res. Commun., 379, 1072-1075.

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Inhibitors

Inhibitors	Comment	Organism	Structure
platelet factor 4	upon preincubation with factor Xa and heparin, platelet factor 4 at about 250 nM decreases the kcat of peptide substrate S2765 hydrolysis about fivefold and that of prothrombin activation about 25fold. In the presence of saturating fVa, inhibition of factor Xa by platelet factor is abolished, while in the presence of limiting factor Va, platelet factor 4 alters the interaction of factor Xa with factor Va. High concentrations of platelet factor 4 restore factor Xa activity toward peptide S2765 and prothrombin, indicating a dual effect of platelet factor 4 on factor Xa activities. Heparin is required to promote the formation of an fXaPF4 complex	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-Gly-Arg-4-nitroanilide + H2O	synthetic substrate S2765	Homo sapiens	Arg-Gly-Arg + 4-nitroaniline	-	?
D-Phe-Pip-Arg-4-nitroanilide + H2O	synthetic substrate S2238	Homo sapiens	D-Phe-Pip-Arg + 4-nitroaniline	-	?
prothrombin + H2O	-	Homo sapiens	thrombin + thrombin propeptide	-	?

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Release 2023.1 (January 2023)