Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibitors of blood coagulation factors Xa and IIa, i.e. PD0313052 and argatroban, synergize to reduce thrombus weight and thrombin generation in vivo and in vitro | Homo sapiens | |
PD0313052 | i.e. [(2R, 6S)-2-(5-carbamimidoyl-2-hydroxy-phenyl)-4-[5-(2,6-dimethyl-piperidin-1-yl)-pentyl]-3-oxo-3,4-dihydro-quinoxaline-6-carboxylic acid] | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PD0313052 and argatroban, inhibitors of blood coagulation factors Xa and IIa, synergize to reduce thrombus weight and thrombin generation in vivo and in vitro | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PD0313052 and argatroban, inhibitors of blood coagulation factors Xa and IIa, synergize to reduce thrombus weight and thrombin generation in vivo and in vitro | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
FXa | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000497 | - |
- |
Homo sapiens | PD0313052 |