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Literature summary for 3.4.21.6 extracted from

  • Bianchini, E.P.; Pike, R.N.; Le Bonniec, B.F.
    The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions (2004), J. Biol. Chem., 279, 3671-3679.
    View publication on PubMed
Search for more literature for 3.4.21.6

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000045
-
 prothrombin pH 7.4, 25°C, mutant enzyme E36K/E37K/E39K Homo sapiens
0.000057
-
 prothrombin pH 7.4, 25°C, mutant enzyme E36Q/E37Q/E39Q Homo sapiens
0.000086
-
 prothrombin pH 7.4, 25°C, wild-type enzyme Homo sapiens
0.000111
-
 prothrombin pH 7.4, 25°C, mutant enzyme E74K/E76K/E77K Homo sapiens
0.000129
-
 prothrombin pH 7.4, 25°C, mutant enzyme E74Q, E76Q/E77Q Homo sapiens
0.052
-
 S2765 pH 7.4, 25°C, mutant enzyme E36Q/E37Q/E39Q Homo sapiens
0.059
-
 S2765 pH 7.4, 25°C, mutant enzyme E36K/E37K/E39K Homo sapiens
0.061
-
 S2765 pH 7.4, 25°C, wild-type enzyme Homo sapiens
0.094
-
 S2765 pH 7.4, 25°C, mutant enzyme E74Q, E76Q/E77Q Homo sapiens
0.112
-
 S2765 pH 7.4, 25°C, mutant enzyme E74K/E76K/E77K Homo sapiens
0.318
-
 S2222 pH 7.4, 25°C, wild-type enzyme Homo sapiens
0.333
-
 S2222 pH 7.4, 25°C, mutant enzyme E36Q/E37Q/E39Q Homo sapiens
0.339
-
 S2222 pH 7.4, 25°C, mutant enzyme E36K/E37K/E39K Homo sapiens
0.529
-
 S2222 pH 7.4, 25°C, mutant enzyme E74Q, E76Q/E77Q Homo sapiens
0.739
-
 S2222 pH 7.4, 25°C, mutant enzyme E74K/E76K/E77K Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-VQFRILGDQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoyl-VQFR + ILGDQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
2-aminobenzoyl-VQFRSAGDQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoyl-VQFR + SAGDQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
2-aminobenzoyl-VQFRSLEDQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoyl-VQFR + SLEDQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
2-aminobenzoyl-VQFRSLTDQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoyl-VQFR + SLTDQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
2-aminobenzoyl-VQFRSVGDQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoyl-VQFR + SCGDQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
2-aminobenzoyl-VQFRTLGDQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoyl-VQFR + TLGDQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?
S2222 + H2O
-
 Homo sapiens ?
-
 ?
S2765 + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.6
-
 prothrombin pH 7.4, 25°C, mutant enzyme E36K/E37K/E39K, activated by factor Va Homo sapiens
0.6
-
 prothrombin pH 7.4, 25°C, mutant enzyme E36Q/E37Q/E39Q, activated by factor Va Homo sapiens
5.7
-
 prothrombin pH 7.4, 25°C, wild-type enzyme, activated by factor Va Homo sapiens
7.3
-
 prothrombin pH 7.4, 25°C, mutant enzyme E74K/E76K/E77K, activated by factor Va Homo sapiens
10.5
-
 prothrombin pH 7.4, 25°C, mutant enzyme E74Q, E76Q/E77Q, activated by factor Va Homo sapiens
139
-
 S2222 pH 7.4, 25°C, mutant enzyme E74K/E76K/E77K Homo sapiens
148
-
 S2222 pH 7.4, 25°C, mutant enzyme E74Q, E76Q/E77Q Homo sapiens
196
-
 S2222 pH 7.4, 25°C, mutant enzyme E36K/E37K/E39K Homo sapiens
200
-
 S2222 pH 7.4, 25°C, mutant enzyme E36Q/E37Q/E39Q Homo sapiens
211
-
 S2222 pH 7.4, 25°C, wild-type enzyme Homo sapiens
214
-
 S2765 pH 7.4, 25°C, mutant enzyme E36Q/E37Q/E39Q Homo sapiens
215
-
 S2765 pH 7.4, 25°C, mutant enzyme E36K/E37K/E39K Homo sapiens
254
-
 S2765 pH 7.4, 25°C, wild-type enzyme Homo sapiens
269
-
 S2765 pH 7.4, 25°C, mutant enzyme E74K/E76K/E77K Homo sapiens
270
-
 S2765 pH 7.4, 25°C, mutant enzyme E74Q, E76Q/E77Q Homo sapiens