Literature summary for 3.4.21.6 extracted from

Verner, E.; Katz, B.A.; Spencer, J.R.; Allen, D.; Hataye, J.; Hruzewicz, W.; Hui, H.C.; Kolesnikov, A.; Li, Y.; Luong, C.; Martelli, A.; Radika, K.; Rai, R.; She, M.; Shrader, W.; Sprengeler, P.A.; Trapp, S.; Wang, J.; Young, W.B.; Mackman, R.L.
Development of serine protease inhibitors displaying a multicentered short 2.3 ANG hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa (2001), J. Med. Chem., 44, 2753-2771.

Inhibitors

Inhibitors	Comment	Organism
2-(2-hydroxy-5-methylbiphenyl-3-yl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(2-hydroxybiphenyl-3-yl)benzofuran-5-carboxamidine	-	Homo sapiens
2-(2-hydroxyphenyl)1H-benzoimidazole-5-carboxamidine	-	Homo sapiens
2-(2-hydroxyphenyl)1H-indole-5-carboxamidine	-	Homo sapiens
2-(2-hydroxyphenyl)3-methyl-3H-benzoimidazole-5-carboxamidine	-	Homo sapiens
2-(2-methoxybiphenyl-3-yl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(3,5-dibromo-2-hydroxyphenyl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(3-bromo-2-hydroxy-5-nitrophenyl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(3-bromo-2-hydroxyphenyl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(5-bromo-2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(5-chloro-2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-(5-nitro-2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	-	Homo sapiens
2-biphenyl-3-yl-1H-indole-5-carboxamidine	-	Homo sapiens
additional information	structure-activity relationship, development and synthesis of zinc-binding independent inhibitors, overview	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction	Comment	Organism	Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin	scutelarin has similar specificity, catalytic residues are Ser195 and His57, mechanism	Homo sapiens	a

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
prothrombin + H2O	-	Homo sapiens	thrombin + ?	-	?

Synonyms	Comment	Organism
factor Xa	-	Homo sapiens
More	the enzyme belongs to the peptidase family S1, i.e. trypsin family	Homo sapiens

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	room temperature, assay at	Homo sapiens

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.000014	-	2-(5-nitro-2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.000043	-	2-(3-bromo-2-hydroxyphenyl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.000052	-	2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.000078	-	2-(3-bromo-2-hydroxy-5-nitrophenyl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.000078	-	2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.000089	-	2-(3,5-dibromo-2-hydroxyphenyl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.00021	-	2-(2-hydroxy-5-methylbiphenyl-3-yl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.00021	-	2-(5-bromo-2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.00034	-	2-(5-chloro-2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.0027	-	2-(2-hydroxyphenyl)1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.0068	-	2-(2-hydroxybiphenyl-3-yl)benzofuran-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.014	-	2-(2-hydroxyphenyl)1H-benzoimidazole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.019	-	2-(2-methoxybiphenyl-3-yl)-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.03	-	2-(2-hydroxyphenyl)3-methyl-3H-benzoimidazole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens
0.043	-	2-biphenyl-3-yl-1H-indole-5-carboxamidine	pH 7.4, 22°C	Homo sapiens