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Literature summary for 3.4.21.6 extracted from

  • Chopin, V.; Salzet, M.; Baert, J.L.; Vandenbulcke, F.; Sautiere, P.E.; Kerckaert, J.P.; Malecha, J.
    Therostasin, a novel clotting factor Xa inhibitor from the rhynchobdellid leech, Theromyzon tessulatum (2000), J. Biol. Chem., 275, 32701-32707.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
therostasin highly specific, natural, tight-binding inhibitor, 5200fold purified from the rhynchobdellid leech Theromyzon tessulatum, DNA and amino acid sequence determination and analysis, protein of 8990 Da encoded by 825 bp, SwissProt accession number P82355, GenBank accession number AF239803, causes a 4fold increase in blood clotting velocity Mammalia

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S2238 + H2O
-
Mammalia ?
-
?

Synonyms

Synonyms Comment Organism
clotting factor Xa
-
Mammalia
factor Xa
-
Mammalia
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Mammalia

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Mammalia

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
assay at Mammalia

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000034
-
therostasin
-
Mammalia