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Literature summary for 3.4.21.6 extracted from

  • Leadley, R.J., Jr.; Chi, L.; Porcari, A.R.
    Non-hemostatic activity of coagulation factor Xa: potential implications for various diseases (2001), Curr. Opin. Pharmacol., 1, 169-175.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is a target for antithrombotic agents Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-
extracellular
-
Rattus norvegicus
-
-
extracellular
-
Sus scrofa
-
-
extracellular
-
Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview ?
-
?
additional information Rattus norvegicus enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview ?
-
?
additional information Sus scrofa enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview ?
-
?
additional information Oryctolagus cuniculus enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview ?
-
?
prothrombin + H2O Sus scrofa enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces thrombin + ?
-
?
prothrombin + H2O Oryctolagus cuniculus enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces thrombin + ?
-
?
prothrombin + H2O Homo sapiens enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells thrombin + ?
-
?
prothrombin + H2O Rattus norvegicus enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells thrombin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Rattus norvegicus
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Sus scrofa
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
blood
-
Rattus norvegicus
-
blood
-
Sus scrofa
-
blood
-
Oryctolagus cuniculus
-
blood clot bound to Homo sapiens
-
blood clot bound to Rattus norvegicus
-
blood clot bound to Sus scrofa
-
blood clot bound to Oryctolagus cuniculus
-
additional information factor Xa binds to cell surfaces Homo sapiens
-
additional information factor Xa binds to cell surfaces Rattus norvegicus
-
additional information factor Xa binds to cell surfaces Sus scrofa
-
additional information factor Xa binds to cell surfaces Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview Homo sapiens ?
-
?
additional information enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview Rattus norvegicus ?
-
?
additional information enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview Sus scrofa ?
-
?
additional information enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview Oryctolagus cuniculus ?
-
?
prothrombin + H2O
-
Homo sapiens thrombin + ?
-
?
prothrombin + H2O
-
Rattus norvegicus thrombin + ?
-
?
prothrombin + H2O
-
Sus scrofa thrombin + ?
-
?
prothrombin + H2O
-
Oryctolagus cuniculus thrombin + ?
-
?
prothrombin + H2O enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces Sus scrofa thrombin + ?
-
?
prothrombin + H2O enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces Oryctolagus cuniculus thrombin + ?
-
?
prothrombin + H2O enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells Homo sapiens thrombin + ?
-
?
prothrombin + H2O enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells Rattus norvegicus thrombin + ?
-
?

Synonyms

Synonyms Comment Organism
coagulation factor Xa
-
Homo sapiens
coagulation factor Xa
-
Rattus norvegicus
coagulation factor Xa
-
Sus scrofa
coagulation factor Xa
-
Oryctolagus cuniculus
factor Xa
-
Homo sapiens
factor Xa
-
Rattus norvegicus
factor Xa
-
Sus scrofa
factor Xa
-
Oryctolagus cuniculus
FXa
-
Homo sapiens
FXa
-
Rattus norvegicus
FXa
-
Sus scrofa
FXa
-
Oryctolagus cuniculus
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Rattus norvegicus
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Sus scrofa
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Oryctolagus cuniculus