Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.6 extracted from

  • Banerjee, M.; Majumder, R.; Weinreb, G.; Wang, J.; Lentz, B.R.
    role of procoagulant lipids in human prothrombin activation. 2. Soluble phosphatidylserine upregulates and directs factor Xa to appropriate peptide bonds in prothrombin (2002), Biochemistry, 41, 950-957.
    View publication on PubMed
Search for more literature for 3.4.21.6

Activating Compound

Activating Compound Comment Organism Structure
1,2-dicaproylphosphatidylserine soluble, upregulates 60fold, and directs factor Xa to appropriate peptide bonds in prothrombin Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens prothrombin activation requires proteolysis of 2 bonds and thus involves 2 possible activation pathways, parallel-sequential activation model thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O hydrolysis of Arg322-Ile323 produces meizothrombin as an intermediate, while hydrolysis of Arg273-Thr274 produces prethrombin 2-fragment 1.2 Homo sapiens thrombin + ?
-
 ?
prothrombin + H2O prothrombin activation requires proteolysis of 2 bonds and thus involves 2 possible activation pathways, parallel-sequential activation model Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens