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Literature summary for 3.4.21.59 extracted from

  • Atiakshin, D.; Buchwalow, I.; Samoilova, V.; Tiemann, M.
    Tryptase as a polyfunctional component of mast cells (2018), Histochem. Cell Biol., 149, 461-477 .
    View publication on PubMed
Search for more literature for 3.4.21.59

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
secretory granule
-
 Homo sapiens 30141
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrinogen + H2O Homo sapiens
-
 ?
-
 ?
kininogen + H2O Homo sapiens
-
 ?
-
 ?
pro-matrix metalloproteinase-1 + H2O Homo sapiens
-
 matrix metalloproteinase-1 + ?
-
 ?
pro-matrix metalloproteinase-13 + H2O Homo sapiens
-
 matrix metalloproteinase-13 + ?
-
 ?
pro-matrix metalloproteinase-3 + H2O Homo sapiens
-
 matrix metalloproteinase-3 + ?
-
 ?
pro-matrix metalloproteinase-9 + H2O Homo sapiens
-
 matrix metalloproteinase-9 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrinogen + H2O
-
 Homo sapiens ?
-
 ?
kininogen + H2O
-
 Homo sapiens ?
-
 ?
pro-matrix metalloproteinase-1 + H2O
-
 Homo sapiens matrix metalloproteinase-1 + ?
-
 ?
pro-matrix metalloproteinase-13 + H2O
-
 Homo sapiens matrix metalloproteinase-13 + ?
-
 ?
pro-matrix metalloproteinase-3 + H2O
-
 Homo sapiens matrix metalloproteinase-3 + ?
-
 ?
pro-matrix metalloproteinase-9 + H2O
-
 Homo sapiens matrix metalloproteinase-9 + ?
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
alpha-tryptase isoform Homo sapiens
beta-tryptase main isoform Homo sapiens
delta-tryptase isoform Homo sapiens
gamma-tryptase isoform Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in the pathogenesis of various diseases, including cardio-vascular, respiratory, digestive, reproductive, and nervous system disorders, such as multiple sclerosis and autoimmune encephalomyelitis, as well as diseases of the musculoskeletal system, skin disorders, sepsis, sudden infant death syndrome, and others. The enzyme also participates in angiogenesis, fibrous and amorphous component degradation of the extracellular matrix of the connective tissue and growth factor release. The enzyme boosts wound healing and tumour deposition. The enzyme has the ability to stimulate cultivated vascular endothelial cells to form provascular tubules Homo sapiens