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Literature summary for 3.4.21.59 extracted from

  • Ribatti, D.; Ranieri, G.
    Tryptase, a novel angiogenic factor stored in mast cell granules (2015), Exp. Cell Res., 332, 157-162 .
    View publication on PubMed
Search for more literature for 3.4.21.59

Inhibitors

Inhibitors Comment Organism Structure
gabexate mesilate
-
 Homo sapiens
nafamostat mesilate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
 Homo sapiens 30141
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
134000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + ?
-
 ?
Fibronectin + H2O Homo sapiens
-
 ?
-
 ?
pro-matrix metalloproteinase-9 + H2O Homo sapiens
-
 matrix metalloproteinase-9 + ?
-
 ?
Type IV collagen + H2O Homo sapiens
-
 ?
-
 ?
urokinase plasminogen activator + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + ?
-
 ?
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
pro-matrix metalloproteinase-9 + H2O
-
 Homo sapiens matrix metalloproteinase-9 + ?
-
 ?
Type IV collagen + H2O
-
 Homo sapiens ?
-
 ?
urokinase plasminogen activator + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
alpha-tryptase isoform Homo sapiens
beta-tryptase main isoform Homo sapiens
delta-tryptase isoform Homo sapiens
gamma-tryptase isoform Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in angiogenesis after its release from activated mast cell granules. The enzyme is released with histamine from human skin mast cells in acute and chronic in vivo responses to allergens. The enzyme is a potent activator of fibroblast migration and proliferation, and collagen synthesis, stimulating tissue repair in wound healing and fibrosis. The enzyme tryptase plays an important role in host defense, linking adaptive and innate immunity Homo sapiens