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Literature summary for 3.4.21.59 extracted from
- The role of mast cell specific chymases and tryptases in tumor angiogenesis (2015), BioMed Res. Int., 2015, 142359 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | Mus musculus | - |
fibrin + ? | - |
? |  |
| fibrinogen + H2O | Homo sapiens | - |
fibrin + ? | - |
? | |
| plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? | |
| plasminogen + H2O | Homo sapiens | - |
plasmin + ? | - |
? | |
| protease activated receptor-2 + H2O | Mus musculus | - |
? | - |
? | |
| protease activated receptor-2 + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mast cell | - |
Mus musculus | - |
| mast cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | - |
Mus musculus | fibrin + ? | - |
? | |
| fibrinogen + H2O | - |
Homo sapiens | fibrin + ? | - |
? | |
| additional information | the enzyme cleaves preferentially after Lys/Arg residues | Mus musculus | ? | - |
? | |
| additional information | the enzyme cleaves preferentially after Lys/Arg residues | Homo sapiens | ? | - |
? | |
| plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? | |
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
| protease activated receptor-2 + H2O | - |
Mus musculus | ? | - |
? | |
| protease activated receptor-2 + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Mus musculus |
| tetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-tryptase | major circulating isoform | Homo sapiens |
| beta-tryptase | major type stored in secretory granules | Homo sapiens |
| mast cell specific tryptase | - |
Mus musculus |
| mast cell specific tryptase | - |
Homo sapiens |
| MCP-6 | - |
Mus musculus |
| MCP-7 | - |
Mus musculus |
| Mcpt6 | - |
Mus musculus |
| TPSAB1 | - |
Mus musculus |
| TPSAB1 | - |
Homo sapiens |
| TPSB2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | tryptase (MCP-6 and MCP-7) expression and activity are increased during progression of skin tumors in mice | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tryptase interacts directly with endothelial cells to induce angiogenesis | Homo sapiens |
| physiological function | tryptase interacts directly with endothelial cells to induce angiogenesis. Tryptase affects angiogenesis in myocardial microvascular endothelial cells via angiopoietin-2/Tie-2 | Mus musculus |
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Release 2023.1 (January 2023)
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