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Literature summary for 3.4.21.59 extracted from

  • Pang, L.; Nie, M.; Corbett, L.; Sutcliffe, A.; Knox, A.J.
    Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities (2006), J. Immunol., 176, 3788-3795.
    View publication on PubMed
Search for more literature for 3.4.21.59

Activating Compound

Activating Compound Comment Organism Structure
heparin activates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
leupeptin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the lack of eosinophils in asthmatic airway smooth muscle bundles in contrast to the large number of mast cells is a key feature of asthma and is caused by beta-tryptase abrogating the eosinophil chemotactic activities of ASM cell-derived eosinophil chemoattractants such as eotaxin and RANTES, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation purified from lung Homo sapiens
-
lung purified commercial preparation Homo sapiens
-
mast cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1000
-
 purified commercial preparation from lung Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the lack of eosinophils in asthmatic airway smooth muscle bundles in contrast to the large number of mast cells is a key feature of asthma and is caused by beta-tryptase abrogating the eosinophil chemotactic activities of ASM cell-derived eosinophil chemoattractants such as eotaxin and RANTES, overview Homo sapiens ?
-
 ?
N-benzoyl-DL-arginine-4-nitroanilide + H2O
-
 Homo sapiens N-benzoyl-DL-arginine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
beta-tryptase
-
 Homo sapiens
mast cell-specific protease
-
 Homo sapiens