General Stability | Organism |
---|---|
heparin-proteoglycan stabilizes the active enzyme monomers | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombin III | - |
Homo sapiens | |
BPTI | - |
Homo sapiens | |
SBTII | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secreted from activated mast cells | Homo sapiens | - |
- |
secretory granule | - |
Homo sapiens | 30141 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
enzyme-antithrombin III complex, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component 3 + H2O | Homo sapiens | digestion | ? | - |
? | |
Fibrinogen + H2O | Homo sapiens | digestion | ? | - |
? | |
Fibronectin + H2O | Homo sapiens | digestion | ? | - |
? | |
additional information | Homo sapiens | beta-tryptase is involved in the pathogenesis of airway inflammation, the enzyme accounts for more than 25% or total protein in human mast cells, activated cells release the enzyme along with histamine and heparin proteoflycans, overview | ? | - |
? | |
pro-matrix metalloprotease-3 + H2O | Homo sapiens | digestion | ? | - |
? | |
Pro-urokinase + H2O | Homo sapiens | digestion | ? | - |
? | |
protease-activated receptor-2 + H2O | Homo sapiens | digestion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
genes TPSAB 1 and TPSB2 | - |
Purification (Comment) | Organism |
---|---|
native enzyme by gel filtration | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
reconstitution of active tetramer from inactive monomers, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | synthesis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component 3 + H2O | digestion | Homo sapiens | ? | - |
? | |
Fibrinogen + H2O | digestion | Homo sapiens | ? | - |
? | |
Fibronectin + H2O | digestion | Homo sapiens | ? | - |
? | |
additional information | beta-tryptase is involved in the pathogenesis of airway inflammation, the enzyme accounts for more than 25% or total protein in human mast cells, activated cells release the enzyme along with histamine and heparin proteoflycans, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme is a serine protease that is a major and selective component of the secretory granules of all human mast cells, active monomers of human beta-tryptase have expanded substrate specificities, overview | Homo sapiens | ? | - |
? | |
pro-matrix metalloprotease-3 + H2O | digestion | Homo sapiens | ? | - |
? | |
Pro-urokinase + H2O | digestion | Homo sapiens | ? | - |
? | |
protease-activated receptor-2 + H2O | digestion | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | a homotetramer with the active sites facing into the central cavity of the four monomers, the monomers are active, when stabilized by heparin-proteoglycan, and have expanded substrate specificities, overview | Homo sapiens |
tetramer | a homotetramer with the active sites facing into the central cavity of the four monomers, the monomers are active, when stabilized by heparin-proteoglycan, and have expanded substrate specificities, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
beta-tryptase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
inactivation of active monomers at neutral pH without stabilization by heparin-proteoglycans | Homo sapiens |