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Literature summary for 3.4.21.59 extracted from

  • Tatler, A.L.; Porte, J.; Knox, A.; Jenkins, G.; Pang, L.
    Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis (2008), Biochem. Biophys. Res. Commun., 370, 239-242.
    View publication on PubMed
Search for more literature for 3.4.21.59

Inhibitors

Inhibitors Comment Organism Structure
FUT175 a selective tryptase inhibitor Homo sapiens
leupeptin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
TGFbeta + H2O Homo sapiens tryptase activates TGFbeta, a key remodelling factor in asthma, in human airway smooth muscle cells via direct proteolysis in a PAR2-independent manner, TGFbeta is produced as a latent complex and the main limiting step in TGFb bioavailability is its activation, overview activated TGFbeta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
airway smooth muscle
-
 Homo sapiens
-
commercial preparation purified from lung Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
TGFbeta + H2O activation Homo sapiens activated TGFbeta + ?
-
 ?
TGFbeta + H2O tryptase activates TGFbeta, a key remodelling factor in asthma, in human airway smooth muscle cells via direct proteolysis in a PAR2-independent manner, TGFbeta is produced as a latent complex and the main limiting step in TGFb bioavailability is its activation, overview Homo sapiens activated TGFbeta + ?
-
 ?