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Literature summary for 3.4.21.59 extracted from
- Human b-tryptase is a ring-like tetramer with active sites facing a central pore (1998), Nature, 392, 306-311.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potent and selective inhibitor of tryptase will be an essential tool to determine the role of tryptase in inflammation and other processes, tryptase plays a role in asthma and other allergic and inflammatory skin diseases like psoriasis and atopic dermatitis | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| 3A crystal structure in a complex with 4-amidinophenyl pyruvic acid, large crystals of the tetragonal space group P4(1) with cell axes a = b = 82.93 A | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| stabilized by heparin proteoglycans | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LDTI | only naturally occuring inhibitor, leech-derived tryptase inhibitor | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| secretory granule | - |
Homo sapiens | 30141 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | - |
Homo sapiens | fibrinogen fragments | - |
? |  |
| additional information | 4 closely related isoenzymes, tryptase alpha, I tryptase, tryptase II/beta and III tryptase, preferentially cleaves peptide substrates carboxy-terminal to arginine and lysine residues, hydrolyses bronchodilatatory neuropeptides, vasoactive intestinal peptide and peptide histidine methionine in vitro, cleaves fibrinogen and fibronectin inactivating, and activating the zymogens of stromelysin-1 and urokinase-type plasminogen activator | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| human beta-tryptase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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