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Literature summary for 3.4.21.59 extracted from

  • Combrink, K.D.; Guelgeze, H.B.; Meanwell, N.A.; Pearce, B.C.; Zulan, P.; Bisacchi, G.S.; Roberts, D.G.; Stanley, P.; Seiler, S.M.
    1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase (1998), J. Med. Chem., 41, 4854-4860.
    View publication on PubMed
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Application

Application Comment Organism
medicine potent and selective inhibitor of tryptase will be an essential tool to determine the role of tryptase in inflammation and other processes, tryptase plays a role in asthma and other allergic and inflammatory skin diseases like psoriasis and atopic dermatitis Homo sapiens

General Stability

General Stability Organism
stabilized by heparin proteoglycans Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 4-[[(phenylmethoxy)carbonyl]amino]-benzoate
-
 Homo sapiens
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 5-[[(phenylmethoxy)carbonyl]amino]-pentanoate
-
 Homo sapiens
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl N-[(phenylmethoxy)carbonyl]-beta-alanate
-
 Homo sapiens
1,2-benzisothiazol-3-one 1,1-dioxide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
 Homo sapiens 30141
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
human mast cell tryptase
-
 Homo sapiens