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Literature summary for 3.4.21.59 extracted from

  • Stubbs, M.T.; Morenweiser, R.; Sturzebecher, J.; Bauer, M.; Bode, W.; Huber, R.; Piechottka, G.P.; Matschiner, G.; Sommerhoff, C.P.; Fritz, H.; Auerswald, E.A.
    The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition (1997), J. Biol. Chem., 272, 19931-19937.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
gabexate mesilate
-
 Homo sapiens
additional information unique tryptase inasmuch as it has no endogenous inhibitors Homo sapiens
rLDTI recombinant leech-derived tryptase inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
 Homo sapiens 30141
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homotetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
human mast cell tryptase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000012
-
 rLDT1 pH 7.6, 25°C Homo sapiens