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Literature summary for 3.4.21.59 extracted from
- Tryptase: a mast cell serine protease (1994), Methods Enzymol., 244, 88-100.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Bos taurus |
- |
Canis lupus familiaris |
General Stability
| General Stability | Organism |
|---|---|
| heparin stabilizes human and dog enzyme | Homo sapiens |
| heparin stabilizes human and dog enzyme | Canis lupus familiaris |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha1-antitrypsin | human and dog enzyme insensitive | Canis lupus familiaris | |
| alpha1-antitrypsin | human and dog enzyme insensitive | Homo sapiens | |
| alpha1-antitrypsin | rat peritoneal mast cell enzyme, no inhibition of skin enzyme | Rattus norvegicus | |
| antipain | - |
Homo sapiens |  |
| antipain | - |
Rattus norvegicus | |
| Aprotinin | - |
Bos taurus | |
| Aprotinin | - |
Homo sapiens | |
| Aprotinin | - |
Rattus norvegicus | |
| Soybean trypsin inhibitor | inhibition of rat peritoneal mast cell enzyme, no inhibition of skin enzyme | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mast cell granule | - |
Homo sapiens | 42629 | - |
| mast cell granule | - |
Rattus norvegicus | 42629 | - |
| mast cell granule | - |
Bos taurus | 42629 | - |
| mast cell granule | - |
Canis lupus familiaris | 42629 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 134000 | - |
human | Homo sapiens |
| 144000 | - |
dog | Canis lupus familiaris |
| 145000 | 160000 | rat mast cell enzyme | Rattus norvegicus |
| 360000 | - |
bovine | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | - |
? | - |
? | |
| additional information | Homo sapiens | potential biological activities of human enzyme: 1. fibrinogenolysis, prevents clotting at local sites of mast cell activation | ? | - |
? | |
| additional information | Homo sapiens | 2. augmentation of histamine-mediated contractility of airway smooth, increases airway hyperreactivity to histamine and allergens, 3. degradation of vasoactive intestinal peptide, decreases endogenous bronchodilatory activity in lung 4. activation of prostromelysin, facilitates activation of procollagenase and tissue remodeling, 5. degradation of fibronectin, tissue remodeling, 6. stimulation of fibroblast proliferation, enhances fibrogenesis or wound repair | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Canis lupus familiaris | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Bos taurus |
| glycoprotein | - |
Canis lupus familiaris |
| glycoprotein | carbohydrate is present on each subunit | Homo sapiens |
| glycoprotein | carbohydrate is present on each subunit | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Canis lupus familiaris |
| skin-derived enzyme is not associated with trypstatin | Rattus norvegicus |
| with an associated protein (trypstatin) that inhibits the protease activity above pH 7.5 (enzyme from peritoneal mast cells) | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Homo sapiens | - |
| mast cell | - |
Homo sapiens | - |
| mast cell | - |
Canis lupus familiaris | - |
| mast cell | peritoneal | Rattus norvegicus | - |
| mast cell | from liver capsule | Bos taurus | - |
| skin | - |
Homo sapiens | - |
| skin | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | potential biological activities of human enzyme: 1. fibrinogenolysis, prevents clotting at local sites of mast cell activation | Homo sapiens | ? | - |
? | |
| additional information | 2. augmentation of histamine-mediated contractility of airway smooth, increases airway hyperreactivity to histamine and allergens, 3. degradation of vasoactive intestinal peptide, decreases endogenous bronchodilatory activity in lung 4. activation of prostromelysin, facilitates activation of procollagenase and tissue remodeling, 5. degradation of fibronectin, tissue remodeling, 6. stimulation of fibroblast proliferation, enhances fibrogenesis or wound repair | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 39000-40000, bovine | Homo sapiens |
| ? | x * 39000-40000, bovine | Rattus norvegicus |
| ? | x * 39000-40000, bovine | Bos taurus |
| ? | x * 39000-40000, bovine | Canis lupus familiaris |
| tetramer | 4 * 30000-40000, mast cell enzyme | Homo sapiens |
| tetramer | 4 * 30000-40000, mast cell enzyme | Rattus norvegicus |
| tetramer | 4 * 30000-40000, mast cell enzyme | Canis lupus familiaris |
| tetramer | 4 * 31000-34000, human | Homo sapiens |
| tetramer | 4 * 31000-34000, human | Rattus norvegicus |
| tetramer | 4 * 31000-34000, human | Canis lupus familiaris |
| tetramer | 4 * 30000-35000, dog | Homo sapiens |
| tetramer | 4 * 30000-35000, dog | Rattus norvegicus |
| tetramer | 4 * 30000-35000, dog | Canis lupus familiaris |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
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