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Literature summary for 3.4.21.53 extracted from

  • Fishovitz, J.; Li, M.; Frase, H.; Hudak, J.; Craig, S.; Ko, K.; Berdis, A.J.; Suzuki, C.K.; Lee, I.
    Active-site-directed chemical tools for profiling mitochondrial Lon protease (2011), ACS Chem. Biol., 6, 781-788.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
dansyl-YRGIT-Abu-B(OH)2 i.e. DBN93, site-directed peptide inhibitor with two-step mechanism Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-casein + H2O
-
Homo sapiens ?
-
?
FRETN 89-98 + H2O peptide-based substrate containing the Y(NO2)-Abz internal fluorescence quenching pair and peptide sequence RGITCSGRQK, also substrate for human protease ClpXP Homo sapiens additional information cleavage of the peptide at Cys-Ser ?
FRETN 89-98Abu + H2O peptide-based substrate containing the Y(NO2)-Abz internal fluorescence quenching pair and peptide sequence RGIT-Abu-SGRQK, no substrate for human protease ClpXP Homo sapiens ?
-
?
lambda phage N protein + H2O
-
Homo sapiens ?
-
?
steroidogenic acute regulatory protein + H2O i.e. StAR protein, an endogenous substrate Homo sapiens ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000021
-
dansyl-YRGIT-Abu-B(OH)2 second KI-value, pH 8.0, 37°C Homo sapiens
0.00135
-
dansyl-YRGIT-Abu-B(OH)2 first KI-value, pH 8.0, 37°C Homo sapiens