BRENDA - Enzyme Database
show all sequences of 3.4.21.53

DNA-binding specificity of the Lon protease alpha-domain from Brevibacillus thermoruber WR-249

Lin, Y.C.; Lee, H.C.; Wang, I.; Hsu, C.H.; Liao, J.H.; Lee, A.Y.; Chen, C.; Wu, S.H.; Biochem. Biophys. Res. Commun. 388, 62-66 (2009)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus subtilis
-
-
-
Brevibacillus thermoruber
-
WR-249
-
Brevibacillus thermoruber WR-249
-
WR-249
-
Escherichia coli
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Bacillus subtilis
?
-
-
-
-
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Escherichia coli
?
-
-
-
-
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Brevibacillus thermoruber
?
-
-
-
-
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Brevibacillus thermoruber WR-249
?
-
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Bacillus subtilis
?
-
-
-
-
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Escherichia coli
?
-
-
-
-
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Brevibacillus thermoruber
?
-
-
-
-
additional information
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
707377
Brevibacillus thermoruber WR-249
?
-
-
-
-
General Information
General Information
Commentary
Organism
physiological function
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
Bacillus subtilis
physiological function
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
Brevibacillus thermoruber
physiological function
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
Escherichia coli
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
Bacillus subtilis
physiological function
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
Brevibacillus thermoruber
physiological function
the alpha-domain from Lon binds to the duplex nucleotide sequence 5'-CTGTTAGCGGGC-3' from pET28a plasmid DNA sequence map and protects it from DNase I digestion. The Brevibacillus thermoruber Lon alpha-domain binds with 5'-CTGTTAGCGGGC-3' double-stranded DNA tighter than Lon alpha-domains from Escherichia coli and Bacillus subtilis, whereas the Brevibacillus thermoruber Lon alpha-domain has dramatically lower affinity for double-stranded DNA with 0 and 50% identity to the 5'-CTGTTAGCGGGC-3' binding sequence
Escherichia coli
Other publictions for EC 3.4.21.53
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732390
Cerletti
Global role of the membrane pr ...
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J. Proteomics
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1
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727373
Cerletti
The LonB protease controls mem ...
Haloferax volcanii
Environ. Microbiol.
16
1779-1792
2014
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2
2
2
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731618
Quiros
ATP-dependent Lon protease con ...
Homo sapiens, Mus musculus
Cell Rep.
8
542-556
2014
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1
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4
4
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731724
Takeuchi
Lon protease negatively affect ...
Pseudomonas protegens, Pseudomonas protegens CHA0
Environ. Microbiol.
16
2538-2549
2014
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1
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1
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3
3
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731762
Goo
HtrA2/Omi influences the stabi ...
Homo sapiens, Mus musculus
Exp. Cell Res.
328
456-465
2014
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2
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731797
Ambro
Mutations to a glycine loop in ...
Homo sapiens
FEBS J.
281
1784-1797
2014
1
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13
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731835
Kereiche
Three-dimensional reconstructi ...
Homo sapiens
Folia Biol. (Praha)
60 Suppl 1
62-65
2014
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3
3
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732469
Gibellini
Sirtuin 3 interacts with Lon p ...
Homo sapiens
Mitochondrion
18
76-81
2014
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732470
Smakowska
Mitochondrial ATP-dependent pr ...
Arabidopsis thaliana
Mitochondrion
19
245-251
2014
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2
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732532
Wohlever
Roles of the N domain of the A ...
Escherichia coli
Mol. Microbiol.
91
66-78
2014
1
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2
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732906
Andrianova
-
Role of alpha-helical domains ...
Escherichia coli
Russ. J. Bioorg. Chem.
40
620-627
2014
1
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2
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2
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3
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731052
Liao
Structures of an ATP-independe ...
Meiothermus taiwanensis
Acta Crystallogr. Sect. D
69
1395-1402
2013
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731056
Li
The N-terminal substrate-recog ...
Meiothermus taiwanensis
Acta Crystallogr. Sect. D
69
1789-1797
2013
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731814
Redelberger
Quality control of a molybdoen ...
Escherichia coli
FEBS Lett.
587
3935-3942
2013
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732825
Vieux
Distinct quaternary structures ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
110
E2002-E2008
2013
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731174
Nakajima
Lon protease of Azorhizobium c ...
Azorhizobium caulinodans, Azorhizobium caulinodans ORS 571
Appl. Environ. Microbiol.
78
6251-6261
2012
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2
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731218
Smith
Mitochondrial calpain 10 is de ...
Oryctolagus cuniculus, Oryctolagus cuniculus New Zealand White
Arch. Biochem. Biophys.
517
144-152
2012
2
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732710
Breidenstein
The Lon protease is essential ...
Pseudomonas aeruginosa
PLoS ONE
7
e49123
2012
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2
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732882
Gur
Protein unfolding and degradat ...
Escherichia coli
Protein Sci.
21
268-278
2012
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8
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1
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8
-
1
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2
2
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-
717017
Fishovitz
Active-site-directed chemical ...
Homo sapiens
ACS Chem. Biol.
6
781-788
2011
-
-
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1
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1
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1
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5
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2
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1
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5
-
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717743
Minami
Regulatory role of cardiolipin ...
Escherichia coli
J. Biochem.
149
519-527
2011
-
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1
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-
718085
Sastre
The Lon protease from the halo ...
Natrialba magadii, Natrialba magadii ATCC 43099
Microbiol. Res.
166
304-313
2011
-
-
1
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3
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1
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6
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1
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1
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1
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3
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1
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-
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1
-
1
1
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-
718095
Bender
Mitochondrial enzymes are prot ...
Saccharomyces cerevisiae
Mol. Biol. Cell
22
541-554
2011
-
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1
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1
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1
1
-
-
-
718113
Yang
Negative regulation of pathoge ...
Pseudomonas amygdali pv. tabaci, Pseudomonas amygdali pv. tabaci ATCC 11528
Mol. Cells
32
317-323
2011
-
1
1
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1
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4
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1
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1
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1
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1
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-
-
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1
1
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-
-
718132
Langklotz
The Escherichia coli replicati ...
Escherichia coli
Mol. Microbiol.
80
1313-1325
2011
-
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3
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1
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-
-
707411
Thomas
Utilization of positional isot ...
Escherichia coli
Biochem. Cell Biol.
88
119-128
2010
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2
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1
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1
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1
1
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-
-
707752
Liao
Binding and cleavage of E. col ...
Escherichia coli
Biophys. J.
98
129-137
2010
-
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2
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1
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709088
Bayot
Identification of novel oxidiz ...
Saccharomyces cerevisiae
J. Biol. Chem.
285
11445-11457
2010
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1
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2
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8
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1
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8
-
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-
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1
1
-
-
-
709125
Sakr
Lon protease quality control o ...
Escherichia coli
J. Biol. Chem.
285
23506-23514
2010
-
-
-
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2
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2
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1
1
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-
709998
Bissonnette
The IbpA and IbpB small heat-s ...
Escherichia coli
Mol. Microbiol.
75
1539-1549
2010
-
-
-
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7
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3
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4
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7
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4
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-
-
-
-
-
-
-
-
710500
Garcia-Nafria
Structure of the catalytic dom ...
Homo sapiens
Protein Sci.
19
987-999
2010
-
-
1
1
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2
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6
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1
1
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1
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1
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1
1
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-
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-
-
-
-
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-
717026
Li
Structure of the N-terminal fr ...
Escherichia coli
Acta Crystallogr. Sect. D
66
865-873
2010
-
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1
1
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3
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1
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1
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-
-
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717035
An
Crystallization and preliminar ...
Thermococcus onnurineus
Acta Crystallogr. Sect. F
66
54-56
2010
-
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1
1
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2
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1
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1
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1
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2
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1
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-
1
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-
-
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-
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-
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-
717190
OBrien
Mechanism of protein splicing ...
Pyrococcus abyssi
Biochem. Biophys. Res. Commun.
403
457-461
2010
-
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1
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9
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3
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1
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1
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9
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1
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-
-
-
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-
717537
Cha
Crystal structure of Lon prote ...
Thermococcus onnurineus
EMBO J.
29
3520-3530
2010
-
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1
1
1
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4
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1
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1
1
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-
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-
-
717991
Duman
Crystal structures of Bacillus ...
Bacillus subtilis
J. Mol. Biol.
401
653-670
2010
-
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1
1
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1
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5
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2
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1
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1
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1
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-
2
-
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-
-
-
-
-
-
-
-
718319
Matsushima
Mitochondrial Lon protease reg ...
Drosophila melanogaster
Proc. Natl. Acad. Sci. USA
107
18410-18415
2010
-
-
1
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-
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2
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3
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1
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-
-
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-
-
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-
-
-
1
1
-
-
-
696047
Chir
The N-terminal sequence after ...
Brevibacillus thermoruber, Brevibacillus thermoruber WR-249
Biochem. Biophys. Res. Commun.
382
762-765
2009
-
-
-
-
1
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4
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
696457
Patterson-Ward
Utilization of synthetic pepti ...
Escherichia coli
Biochim. Biophys. Acta
1794
1355-1363
2009
-
-
-
1
1
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-
-
-
-
-
-
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2
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1
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-
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1
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1
1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697889
Guillon
Frataxin deficiency causes upr ...
Mus musculus
FEBS J.
276
1036-1047
2009
-
1
-
-
-
-
-
-
1
-
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1
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
699582
Griffith
Two functions of the C-termina ...
Escherichia coli
J. Mol. Biol.
388
415-430
2009
-
-
-
-
-
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2
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707165
Malik
Lon protease is essential for ...
Escherichia coli
Antimicrob. Agents Chemother.
53
3103-3105
2009
-
-
-
-
-
-
-
-
-
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-
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707168
Duval
Combined inactivation of lon a ...
Escherichia coli
Antimicrob. Agents Chemother.
53
4944-4948
2009
-
-
-
-
-
-
-
-
-
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707377
Lin
DNA-binding specificity of the ...
Bacillus subtilis, Brevibacillus thermoruber, Brevibacillus thermoruber WR-249, Escherichia coli
Biochem. Biophys. Res. Commun.
388
62-66
2009
-
-
-
-
-
-
-
-
-
-
-
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-
10
-
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4
-
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-
4
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
708563
Ngo
Mitochondrial Lon protease is ...
Homo sapiens
Free Radic. Biol. Med.
46
1042-1048
2009
-
-
-
-
-
-
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1
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2
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
709507
Kim
Changes of physiological and b ...
Salmonella enterica
J. Microbiol. Methods
79
314-320
2009
-
1
-
-
-
-
-
-
-
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1
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1
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-
-
-
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1
1
-
-
-
709994
Ge
Co-evolution of multipartite i ...
Mycoplasma pneumoniae
Mol. Microbiol.
74
1083-1099
2009
-
-
-
-
-
-
-
-
-
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4
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1
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1
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-
-
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-
710314
Lingard
Arabidopsis LON2 is necessary ...
Arabidopsis thaliana
Plant Physiol.
151
1354-1365
2009
-
-
-
-
-
-
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1
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5
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1
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-
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-
-
-
-
-
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1
1
-
-
-
710400
Coleman
Evidence that two ATP-dependen ...
Borreliella burgdorferi
PLoS Pathog.
5
e1000676
2009
-
-
-
-
2
-
-
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-
1
1
-
-
9
-
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-
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-
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5
1
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-
1
-
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1
1
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5
1
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1
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1
2
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710416
Gur
Degrons in protein substrates ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
106
18503-18508
2009
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2
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-
677854
Luo
Lon protease promotes survival ...
Escherichia coli
Arch. Microbiol.
189
181-185
2008
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678475
Lee
Functional mechanics of the AT ...
Brucella abortus, Caulobacter vibrioides, Escherichia coli, Homo sapiens, Mycolicibacterium smegmatis, Pseudomonas aeruginosa, Rattus norvegicus, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium, Thermoplasma acidophilum
Biochim. Biophys. Acta
1784
727-735
2008
3
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8
3
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3
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1
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10
3
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1
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3
4
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3
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5
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1
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8
3
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3
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1
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10
3
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680569
Omi
Contribution of peroxisome-spe ...
Homo sapiens
J. Biochem.
143
649-660
2008
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1
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2
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1
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1
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2
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5
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1
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2
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1
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3
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5
-
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692861
Takaya
Negative regulation of quorum- ...
Pseudomonas aeruginosa
J. Bacteriol.
190
4181-4188
2008
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1
-
1
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1
2
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4
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3
1
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1
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2
1
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2
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1
2
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-
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3
1
-
-
-
-
-
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-
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-
695302
Melnikov
Limited proteolysis of E. coli ...
Escherichia coli
Acta Biochim. Pol.
55
281-296
2008
-
-
-
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1
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2
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1
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1
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1
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-
-
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-
698108
Gur
Recognition of misfolded prote ...
Escherichia coli
Genes Dev.
22
2267-2277
2008
-
-
-
-
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4
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1
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2
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21
-
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1
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4
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1
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-
-
21
-
-
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-
1
-
-
-
-
-
-
-
-
-
-
698595
Simmons
Clp and Lon proteases occupy d ...
Bacillus subtilis
J. Bacteriol.
190
6758-6768
2008
-
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1
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2
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1
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1
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1
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1
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2
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1
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-
1
-
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-
699481
Clemmer
The Lon protease regulates swa ...
Proteus mirabilis
J. Med. Microbiol.
57
931-937
2008
-
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1
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4
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1
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-
-
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-
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-
-
-
700273
Heuveling
A role for Lon protease in the ...
Escherichia coli
Mol. Microbiol.
69
534-547
2008
-
-
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1
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1
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2
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700423
Stanyer
Inactivation of brain mitochon ...
Rattus norvegicus
Neurochem. Int.
53
95-101
2008
-
-
-
-
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-
1
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2
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3
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2
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1
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2
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-
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-
700494
Chen
Thermodynamic characterization ...
Homo sapiens
Nucleic Acids Res.
36
1273-1287
2008
-
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2
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1
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-
1
-
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-
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-
-
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-
-
677574
Ngo
Importance of the lon protease ...
Homo sapiens, Mus musculus, Rattus norvegicus
Ann. N. Y. Acad. Sci.
1119
78-87
2007
1
3
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-
4
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3
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4
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-
3
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3
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2
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1
3
-
2
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4
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3
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-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677594
Brazas
Role of lon, an ATP-dependent ...
Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
51
4276-4283
2007
1
1
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-
1
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-
-
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-
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2
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1
1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677704
Cohn
Contribution of conserved ATP- ...
Campylobacter jejuni, Campylobacter jejuni NCTC 11168
Appl. Environ. Microbiol.
73
7803-7813
2007
-
1
1
-
1
-
-
-
-
-
-
-
-
14
-
-
-
-
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-
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2
-
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1
-
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1
1
1
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1
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678244
Patterson-Ward
Detection and characterization ...
Escherichia coli
Biochemistry
46
13593-13605
2007
1
-
1
-
2
-
-
6
-
-
-
-
-
2
-
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1
-
-
-
-
-
3
-
-
-
-
6
-
-
-
1
-
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-
1
-
1
1
-
2
-
-
-
-
6
-
-
-
-
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-
1
-
-
-
-
3
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
678288
Frase
Peptidyl boronates inhibit Sal ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
46
6647-6657
2007
-
1
1
-
1
-
3
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
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-
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-
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1
1
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-
1
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3
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678943
Bertani
The Pseudomonas putida Lon pro ...
Pseudomonas putida, Pseudomonas putida WCS358
BMC Microbiol.
7
71
2007
-
-
1
-
1
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
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-
1
-
-
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-
1
1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680501
Choy
Lon protease degrades transfer ...
Escherichia coli
J. Bacteriol.
189
6564-6571
2007
-
1
1
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680779
Lu
Roles for the human ATP-depend ...
Homo sapiens
J. Biol. Chem.
282
17363-17374
2007
-
1
-
-
-
-
2
-
2
-
-
1
-
2
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
2
-
-
2
-
-
1
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681804
Marr
The Lon protease of Pseudomona ...
Pseudomonas aeruginosa
Microbiology
153
474-482
2007
2
1
1
-
1
-
-
-
-
-
-
-
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4
-
-
-
-
-
-
-
-
-
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2
1
1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681937
Granot
Turnover of mitochondrial ster ...
Homo sapiens
Mol. Endocrinol.
21
2164-2177
2007
-
1
1
-
1
-
4
-
1
-
-
-
-
6
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
1
1
1
-
1
-
2
4
-
-
1
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682033
Lan
Mutation of Lon protease diffe ...
Pseudomonas syringae
Mol. Plant Microbe Interact.
20
682-696
2007
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
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-
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1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682349
Ostersetzer
Multiple intracellular locatio ...
Arabidopsis thaliana
Plant Cell Physiol.
48
881-885
2007
-
-
1
-
-
-
-
-
5
-
1
-
-
4
-
-
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1
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5
-
1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682848
Makhovskaya
-
Forms of LonB protease from Ar ...
Archaeoglobus fulgidus
Russ. J. Bioorg. Chem.
33
610-613
2007
-
-
1
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
670167
Su
Lon protease of the alpha-prot ...
Agrobacterium tumefaciens
Microbiology
152
1197-1207
2006
-
-
-
-
1
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
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-
1
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-
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-
1
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-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670225
Park
Oligomeric structure of the AT ...
Escherichia coli
Mol. Cell
21
129-134
2006
-
-
-
-
-
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
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-
1
-
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-
-
-
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-
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-
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677923
Lee
An E. coli lon mutant conferri ...
Escherichia coli, Escherichia coli K12 MG1655
Biochem. Biophys. Res. Commun.
345
1579-1585
2006
-
-
1
-
1
-
1
-
-
-
-
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2
-
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-
-
-
-
-
-
-
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1
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-
1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678145
Vineyard
Transient kinetic experiments ...
Escherichia coli
Biochemistry
45
11432-11443
2006
-
-
-
-
-
-
1
-
-
-
-
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2
-
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-
-
-
-
-
1
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-
-
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1
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-
1
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678185
Vineyard
Single-turnover kinetic experi ...
Escherichia coli
Biochemistry
45
4602-4610
2006
-
-
-
-
-
-
-
-
-
-
1
-
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2
-
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1
-
-
-
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3
-
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-
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2
-
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-
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2
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1
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1
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-
-
3
-
-
-
-
-
-
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-
-
-
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-
-
-
-
678206
Frase
Identification of the proteaso ...
Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
45
8264-8274
2006
-
-
2
-
1
-
6
6
-
-
-
-
-
4
-
-
2
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1
4
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5
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2
2
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4
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2
2
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1
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4
6
2
6
-
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2
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1
4
-
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-
-
5
-
-
-
-
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-
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-
678789
Kuroda
A polyphosphate-lon protease c ...
Escherichia coli
Biosci. Biotechnol. Biochem.
70
325-331
2006
1
1
-
-
1
-
1
-
1
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2
-
4
-
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1
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4
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1
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1
1
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1
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1
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1
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-
-
4
-
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-
681850
Lee
Recent developments in the mec ...
Brucella abortus, Escherichia coli, Homo sapiens, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium
Mol. Biosyst.
2
477-483
2006
2
3
-
-
-
-
2
-
1
-
-
-
-
6
-
-
-
-
-
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6
3
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1
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3
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1
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2
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1
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6
3
-
-
-
-
-
-
-
-
-
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-
-
-
-
682726
Rotanova
Slicing a protease: structural ...
Archaeoglobus fulgidus, Bordetella parapertussis, Brevibacillus thermoruber, Escherichia coli, Methanocaldococcus jannaschii, Mycolicibacterium smegmatis, Saccharomyces cerevisiae
Protein Sci.
15
1815-1828
2006
1
-
1
2
7
-
-
-
1
-
-
1
-
9
-
-
2
-
-
-
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7
12
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3
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1
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1
3
2
7
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1
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1
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2
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-
-
-
7
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682821
Tsilibaris
Biological roles of the Lon AT ...
Bacillus subtilis, Brevibacillus brevis, Caulobacter vibrioides, Escherichia coli, Homo sapiens, Myxococcus xanthus, no activity in Lactobacillus sp., no activity in Mycobacterium leprae, no activity in Mycobacterium tuberculosis, no activity in Streptococcus sp., Proteus mirabilis, Pseudomonas syringae, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium, Streptomyces lividans, Vibrio parahaemolyticus, Yersinia pestis
Res. Microbiol.
157
701-713
2006
9
8
-
1
9
-
1
-
2
-
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-
-
18
-
-
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2
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24
1
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9
8
-
-
1
9
-
-
1
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2
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2
-
-
24
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667645
Vineyard
Monitoring the timing of ATP h ...
Escherichia coli
Biochemistry
44
1671-1682
2005
-
-
-
-
-
-
-
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2
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1
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-
-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
668624
Nishii
Cleavage mechanism of ATP-depe ...
Escherichia coli
FEBS Lett.
579
6846-6850
2005
1
-
-
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1
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2
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1
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1
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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669354
Ondrovicova
Cleavage site selection within ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
280
25103-25110
2005
2
-
-
-
-
-
-
-
2
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2
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2
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7
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2
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2
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-
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7
-
-
-
-
-
-
-
-
-
-
-
-
-
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669554
Vera
Lon and ClpP proteases partici ...
Escherichia coli
J. Biotechnol.
119
163-171
2005
-
1
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-
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1
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
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-
669861
Botos
Atomic-resolution crystal stru ...
Archaeoglobus fulgidus
J. Mol. Biol.
351
144-157
2005
-
-
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1
3
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-
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1
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3
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1
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1
3
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1
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1
-
-
-
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-
-
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-
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-
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-
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-
-
670826
Li
Crystal structure of the N-ter ...
Escherichia coli
Protein Sci.
14
2895-2900
2005
-
-
-
1
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-
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-
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3
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1
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-
-
-
-
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-
-
-
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-
663454
Liu
DNA and RNA binding by the mit ...
Homo sapiens
J. Biol. Chem.
279
13902-13910
2004
-
-
-
-
-
-
1
-
1
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-
1
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1
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1
1
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1
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1
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1
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-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667610
Patterson
Correlation of an adenine-spec ...
Escherichia coli
Biochemistry
43
7432-7442
2004
-
-
-
-
-
-
-
-
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2
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1
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1
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1
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1
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-
-
-
-
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-
1
-
-
-
-
-
-
-
-
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-
668464
Besche
The Thermoplasma acidophilum L ...
Thermoplasma acidophilum
Eur. J. Biochem.
271
4361-4365
2004
-
-
-
-
2
-
-
-
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-
2
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7
-
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1
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1
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-
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2
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2
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668465
Rotanova
Classification of ATP-dependen ...
Escherichia coli
Eur. J. Biochem.
271
4865-4871
2004
-
-
-
-
-
-
-
-
-
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-
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2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668468
Lee
Identification of a gene encod ...
Brevibacillus thermoruber, Brevibacillus thermoruber WR-249
Eur. J. Biochem.
271
834-844
2004
1
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-
-
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-
-
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3
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9
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-
-
-
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2
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4
2
2
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1
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-
1
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-
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3
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-
2
-
4
2
2
-
1
-
-
-
-
-
-
-
-
-
-
-
668596
Besche
Mutational analysis of conserv ...
Thermoplasma acidophilum
FEBS Lett.
574
161-166
2004
1
-
-
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7
-
2
-
1
-
2
-
-
4
-
-
1
-
-
-
1
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2
1
-
-
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-
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-
-
1
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7
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2
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1
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2
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1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669248
Nomura
Effects of inorganic polyphosp ...
Escherichia coli
J. Biol. Chem.
279
34406-34410
2004
1
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-
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-
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2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669251
Lee
Functional domains of Brevibac ...
Brevibacillus thermoruber, Brevibacillus thermoruber WR-249
J. Biol. Chem.
279
34903-34912
2004
-
-
1
-
1
-
-
-
-
-
1
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5
-
-
-
-
-
-
-
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-
1
-
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-
-
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-
-
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-
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1
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-
1
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669297
Im
The active site of a lon prote ...
Methanocaldococcus jannaschii
J. Biol. Chem.
279
53451-53457
2004
-
-
-
1
-
-
-
-
-
-
-
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3
-
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1
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670039
Botos
Crystal structure of the AAA+ ...
Escherichia coli
J. Struct. Biol.
146
113-122
2004
-
-
-
1
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-
-
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-
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2
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
670304
Christensen
Overproduction of the Lon prot ...
Escherichia coli
Mol. Microbiol.
51
1705-1717
2004
-
-
-
-
1
-
-
-
-
-
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2
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670308
Jackson
The ATP-dependent ClpXP and Lo ...
Yersinia pestis
Mol. Microbiol.
54
1364-1378
2004
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
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1
-
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-
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-
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-
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1
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1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670878
Vasilyeva
-
Isolation and characterization ...
Escherichia coli
Russ. J. Bioorg. Chem.
30
306-314
2004
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651411
Lu
The ATP-dependent Lon protease ...
Homo sapiens, Mus musculus
Gene
306
45-55
2003
-
-
1
-
-
-
-
-
2
-
2
-
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5
-
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2
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3
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1
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2
-
2
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2
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-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651835
Botos
The catalytic domain of E.coli ...
Escherichia coli, Homo sapiens
J. Biol. Chem.
279
8140-8148
2003
-
-
2
1
1
-
-
-
1
-
1
1
-
3
-
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2
-
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-
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5
2
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2
-
1
1
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1
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1
1
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2
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5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650178
Thomas-Wohlever
Kinetic characterization of th ...
Escherichia coli
Biochemistry
41
9418-9425
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
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1
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1
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1
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1
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-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
651134
Nishii
The unique sites in SulA prote ...
Escherichia coli
Eur. J. Biochem.
269
451-457
2002
-
-
1
-
-
-
-
-
1
-
-
1
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2
-
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2
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1
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1
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651310
Vasilyeva
Domain structure and ATP-induc ...
Escherichia coli
FEBS Lett.
526
66-70
2002
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
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1
1
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1
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1
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651700
Fukui
A membrane-bound archaeal Lon ...
Thermococcus kodakarensis
J. Bacteriol.
184
3689-3698
2002
-
-
1
-
-
-
-
-
1
5
1
-
-
4
-
-
1
-
-
-
-
-
6
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-
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-
-
6
-
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-
-
1
-
-
-
-
-
-
-
-
-
653293
Bota
Lon protease preferentially de ...
Homo sapiens
Nat. Cell Biol.
4
674-680
2002
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
-
1
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-
-
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-
-
-
-
-
-
-
-
685483
Mertova
-
ATP-dependent Lon protease fro ...
Zea mays
Biologia
57
739-745
2002
1
-
-
-
-
-
8
-
1
1
2
-
-
1
-
-
1
-
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1
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1
1
1
-
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1
1
-
-
-
-
-
-
-
-
650090
Rudyak
Mg2+-linked oligomerization mo ...
Mycolicibacterium smegmatis
Biochemistry
40
9317-9323
2001
2
-
1
-
1
-
1
-
-
1
-
-
-
2
-
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2
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-
-
650968
Birghan
A non-canonical lon proteinase ...
Infectious bursal disease virus
EMBO J.
19
114-123
2000
-
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3
-
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2
-
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-
-
3
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
651641
Ebel
A conserved domain in Escheric ...
Escherichia coli
J. Bacteriol.
181
2236-2243
1999
-
-
1
-
1
-
-
-
1
-
-
2
-
2
-
-
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2
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-
-
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-
-
-
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-
-
-
-
-
653631
Smith
Lon and Clp family proteases a ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
96
6678-6682
1999
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653632
Stahlberg
Mitochondrial Lon of Saccharom ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
96
6787-6790
1999
1
-
-
-
-
1
-
-
3
-
4
-
-
2
-
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1
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1
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-
-
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-
-
-
-
649538
Oh
LonR9 carrying a single Glu614 ...
Escherichia coli, Escherichia coli RGC123
Biochem. Biophys. Res. Commun.
250
32-35
1998
-
-
1
-
1
-
-
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-
-
2
-
-
4
-
-
1
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649846
Roudiak
The lon protease from Mycobact ...
Escherichia coli, Mycolicibacterium smegmatis
Biochemistry
37
377-386
1998
1
-
1
-
3
-
-
-
-
-
1
1
-
5
-
-
1
-
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-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651238
Starkova
Mutations in the proteolytic d ...
Escherichia coli
FEBS Lett.
422
218-220
1998
-
-
-
-
4
-
-
10
-
-
-
-
-
2
-
-
-
-
-
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1
-
-
-
-
9
-
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-
-
-
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4
-
-
-
-
10
-
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-
-
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-
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-
-
1
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
651245
Rasulova
The isolated proteolytic domai ...
Escherichia coli, Escherichia coli MH-1
FEBS Lett.
432
179-181
1998
-
-
1
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
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-
-
-
-
-
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-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651419
van Dyck
The ATP-dependent PIM1 proteas ...
Escherichia coli, Saccharomyces cerevisiae
Genes Dev.
12
1515-1524
1998
-
-
-
-
1
-
-
-
4
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651889
Savel'ev
ATP-dependent proteolysis in m ...
Saccharomyces cerevisiae
J. Biol. Chem.
273
20596-20602
1998
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
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-
-
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-
-
-
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-
-
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-
-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
651911
Hilliard
PinA inhibits ATP hydrolysis a ...
Escherichia coli
J. Biol. Chem.
273
524-527
1998
-
-
-
-
-
-
1
-
-
-
1
-
-
3
-
-
1
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
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-
-
-
-
1
-
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-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653612
van Dijl
The ATPase and protease domain ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
95
10584-10589
1998
-
-
1
-
2
-
-
-
2
-
1
1
-
2
-
-
1
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
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1
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650959
Wagner
Autocatalytic processing of th ...
Saccharomyces cerevisiae
EMBO J.
16
7317-7325
1997
-
-
1
-
2
-
-
-
1
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651873
Fu
Bacterial protease Lon is a si ...
Escherichia coli, Escherichia coli Y1089
J. Biol. Chem.
272
534-538
1997
-
-
1
-
-
-
-
-
-
-
2
2
-
6
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
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2
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651853
Teichmann
Substitution of PIM1 protease ...
Escherichia coli, Saccharomyces cerevisiae
J. Biol. Chem.
271
10137-10142
1996
-
-
1
-
3
-
-
-
2
-
2
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
2
-
-
-
-
-
1
2
-
3
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
29345
Sonezaki
Protein substrates and heat sh ...
Escherichia coli
Appl. Microbiol. Biotechnol.
44
484-488
1995
2
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
29356
Suzuki
Analysis and purification of A ...
Escherichia coli, Saccharomyces cerevisiae
Methods Enzymol.
260
486-494
1995
1
-
-
-
-
-
7
-
2
-
4
2
-
3
-
-
1
-
-
-
-
-
5
2
2
-
-
-
-
-
-
2
-
-
-
1
-
-
2
-
-
-
-
7
-
-
2
-
4
2
-
-
-
1
-
-
-
-
5
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
29359
Sonezaki
Overproduction and purificatio ...
Escherichia coli
Appl. Microbiol. Biotechnol.
42
313-318
1994
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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2
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29360
Goldberg
ATP-dependent protease La (lon ...
Brevibacillus brevis, Escherichia coli, Myxococcus xanthus, Rattus norvegicus, Saccharomyces cerevisiae
Methods Enzymol.
244
350-375
1994
17
-
-
-
-
-
19
1
-
8
9
8
-
6
-
-
-
5
-
1
2
1
39
1
-
-
2
-
-
-
-
10
-
-
-
17
-
-
10
-
-
-
-
19
-
1
-
8
9
8
-
-
-
-
-
1
2
1
39
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
651846
Van Dyck
PIM1 encodes a mitochondrial A ...
Saccharomyces cerevisiae
J. Biol. Chem.
269
238-242
1994
-
-
1
-
-
-
-
-
6
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653881
Suzuki
Requirement for the yeast gene ...
Saccharomyces cerevisiae
Science
264
273-276
1994
-
-
1
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29355
Kutejova
Yeast mitochondrial ATP-depend ...
Rattus norvegicus, Saccharomyces cerevisiae
FEBS Lett.
329
47-50
1993
1
-
-
-
-
-
10
1
3
2
5
-
-
5
-
-
1
-
-
1
1
-
1
2
-
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
10
-
1
3
2
5
-
-
-
-
1
-
1
1
-
1
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
29357
Wang
A human mitochondrial ATP-depe ...
Brevibacillus brevis, Escherichia coli, Homo sapiens, Myxococcus xanthus
Proc. Natl. Acad. Sci. USA
90
11247-11251
1993
-
-
1
-
-
-
-
-
2
-
6
-
-
7
-
-
1
-
-
2
-
-
6
-
4
-
-
-
-
-
-
4
-
-
-
-
-
1
4
-
-
-
-
-
-
-
2
-
6
-
-
-
-
1
-
2
-
-
6
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
29358
Fischer
ATP hydrolysis is not stoichio ...
Escherichia coli
J. Biol. Chem.
268
22502-22507
1993
3
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
1
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29364
Tojo
Cloning and nucleotide sequenc ...
Myxococcus xanthus
J. Bacteriol.
175
2271-2277
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29361
Goldberg
The mechanism and functions of ...
Bos taurus, Escherichia coli, Rattus norvegicus
Eur. J. Biochem.
203
9-23
1992
-
-
-
-
-
2
10
-
-
3
2
3
-
3
-
-
-
3
-
2
-
-
9
1
-
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
2
-
10
-
-
-
3
2
3
-
-
-
-
-
2
-
-
9
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
29363
Ito
Cloning, characterization, and ...
Brevibacillus brevis
J. Bacteriol.
174
2281-2287
1992
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29354
Modha
Effects of ATP analogues on th ...
Escherichia coli
Biochem. Soc. Trans.
18
589
1990
4
-
-
-
-
-
3
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
4
-
-
1
-
-
-
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29353
Baker
Location of enzymatic and DNA- ...
Escherichia coli
FEBS Lett.
244
31-33
1989
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
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-
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-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29352
Chin
Sequence of the lon gene in Es ...
Escherichia coli
J. Biol. Chem.
263
11718-11728
1988
-
-
-
-
-
-
-
-
-
1
2
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29347
Goldberg
The mechanism and regulation o ...
Escherichia coli
Biochem. Soc. Trans.
15
809-811
1987
1
-
-
-
-
-
-
-
-
1
1
1
-
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
1
-
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-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29348
Maurizi
Degradation in vitro of bacter ...
Escherichia coli
J. Biol. Chem.
262
2696-2703
1987
4
-
-
-
-
-
2
-
-
1
-
1
-
3
-
-
-
-
-
-
-
-
8
-
1
-
-
3
-
-
-
3
-
-
-
4
-
-
3
-
-
-
-
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
8
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
29349
Menon
The energy utilized in protein ...
Escherichia coli
J. Biol. Chem.
262
722-726
1987
-
-
-
-
-
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29350
Menon
Binding of nucleotides to the ...
Escherichia coli
J. Biol. Chem.
262
14921-14928
1987
2
-
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
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-
-
-
2
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29351
Menon
Protein substrates activate th ...
Escherichia coli
J. Biol. Chem.
262
14929-14934
1987
2
-
-
-
-
-
1
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29344
Waxman
Selectivity of intracellular p ...
Escherichia coli
Science
232
500-503
1986
7
-
-
-
-
-
1
1
-
-
-
1
-
2
-
-
-
1
-
-
-
-
7
-
1
-
-
-
-
-
-
1
-
-
-
7
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
7
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29346
Edmunds
Role of ATP hydrolysis in the ...
Escherichia coli
J. Cell. Biochem.
32
187-191
1986
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
29342
Waxman
Protease La, the lon gene prod ...
Escherichia coli
J. Biol. Chem.
260
12022-12028
1985
2
-
-
-
-
-
24
2
-
3
-
-
-
2
-
-
-
-
-
-
-
1
10
-
1
-
-
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
24
-
2
-
3
-
-
-
-
-
-
-
-
-
1
10
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
29343
Goldberg
The role of ATP hydrolysis in ...
Escherichia coli
J. Biol. Chem.
260
12029-12034
1985
6
-
-
-
-
-
6
1
-
4
1
-
-
2
-
-
-
-
-
-
-
-
12
1
1
-
-
-
-
-
-
4
-
-
-
6
-
-
4
-
-
-
-
6
-
1
-
4
1
-
-
-
-
-
-
-
-
-
12
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29339
Waxman
Protease La from Escherichia c ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
79
4883-4887
1982
4
-
-
-
-
-
8
2
-
1
1
1
-
2
-
-
1
-
-
-
-
-
7
1
1
-
-
-
-
-
-
4
-
-
-
4
-
-
4
-
-
-
-
8
-
2
-
1
1
1
-
-
-
1
-
-
-
-
7
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
29340
Larimore
Studies of the ATP-dependent p ...
Escherichia coli
J. Biol. Chem.
257
4187-4195
1982
2
-
-
-
-
2
16
1
1
4
-
-
-
2
-
-
1
-
-
-
-
1
5
-
-
-
1
-
-
-
-
4
-
-
-
2
-
-
4
-
-
2
-
16
-
1
1
4
-
-
-
-
-
1
-
-
-
1
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
29341
Desautels
Demonstration of an ATP-depend ...
Rattus norvegicus
J. Biol. Chem.
257
11673-11679
1982
2
-
-
-
-
1
16
-
1
2
1
1
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
1
-
3
-
-
-
2
-
-
3
-
-
1
-
16
-
-
1
2
1
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
29362
Chung
The product of the lon (capR) ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
78
4931-4935
1981
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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