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Literature summary for 3.4.21.53 extracted from

  • Lu, B.; Yadav, S.; Shah, P.G.; Liu, T.; Tian, B.; Pukszta, S.; Villaluna, N.; Kutejova, E.; Newlon, C.S.; Santos, J.H.; Suzuki, C.K.
    Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance (2007), J. Biol. Chem., 282, 17363-17374.
    View publication on PubMed
Search for more literature for 3.4.21.53

Application

Application Comment Organism
additional information roles for lon in linking protein and mitochondrial DNA quality control Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H2O2 blocks enzymatic activity but has no appreciable effect on sequence-specific binding to DNA. 0.1 mM decreases proteolytic activity to ca. 60%, at 0.5, 1, and 4 mM protease activity is reduced to 18, 9, and 5%, respectively Homo sapiens
RNAi lon depletion, cells show little if any mitochondrial DNA damage Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens lon interacts with the mitochondrial genome in cultured cells. Associates with sites distributed primarily within one-half of the genome and preferentially with the control region for mitochondrial DNA replication and transcription, which has a G-rich consensus sequence ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
LS174T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FITC-casein + H2O
-
 Homo sapiens ?
-
 ?
additional information lon interacts with the mitochondrial genome in cultured cells. Associates with sites distributed primarily within one-half of the genome and preferentially with the control region for mitochondrial DNA replication and transcription, which has a G-rich consensus sequence Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
lon
-
 Homo sapiens
lon protease
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens