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Literature summary for 3.4.21.53 extracted from

  • Omi, S.; Nakata, R.; Okamura-Ikeda, K.; Konishi, H.; Taniguchi, H.
    Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes (2008), J. Biochem., 143, 649-660.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant lon expressed in COS-7 cells. HEK293 cell lines stably expressing wild-type lon and its internal deletion mutant delta75-490, by using the retrovirus expression system Homo sapiens

Protein Variants

Protein Variants Comment Organism
delta75-490 dominant negative mutant, exhibits a remarkable decrease in acyl-CoA oxidase and mislocalization of catalase to the cytoplasm. Shows lower beta-oxidation activity than wild-type Homo sapiens
S743A point mutant at the center of the protease catalytic domain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RNAi
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome cells overexpressing lon contain large peroxisomes, but number of peroxisomes in these cells are less than that in wild-type cells Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
pancreas
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA oxidase + H2O exhibits little, if any, in vitro acyl-CoA oxidase processing activity Homo sapiens ?
-
?
hydroxyacyl-coenzyme A dehydrogenase + H2O
-
Homo sapiens ?
-
?
additional information does not process PTS2 protein-containing 3-ketoacyl-coenzyme A thiolase Homo sapiens ?
-
?
PMP70 + H2O
-
Homo sapiens ?
-
?
PTS1 protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
lon
-
Homo sapiens
lon protease
-
Homo sapiens