Cloned (Comment) | Organism |
---|---|
recombinant lon expressed in COS-7 cells. HEK293 cell lines stably expressing wild-type lon and its internal deletion mutant delta75-490, by using the retrovirus expression system | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
delta75-490 | dominant negative mutant, exhibits a remarkable decrease in acyl-CoA oxidase and mislocalization of catalase to the cytoplasm. Shows lower beta-oxidation activity than wild-type | Homo sapiens |
S743A | point mutant at the center of the protease catalytic domain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | cells overexpressing lon contain large peroxisomes, but number of peroxisomes in these cells are less than that in wild-type cells | Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA oxidase + H2O | exhibits little, if any, in vitro acyl-CoA oxidase processing activity | Homo sapiens | ? | - |
? | |
hydroxyacyl-coenzyme A dehydrogenase + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | does not process PTS2 protein-containing 3-ketoacyl-coenzyme A thiolase | Homo sapiens | ? | - |
? | |
PMP70 + H2O | - |
Homo sapiens | ? | - |
? | |
PTS1 protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lon | - |
Homo sapiens |
lon protease | - |
Homo sapiens |