Cloned (Comment) | Organism |
---|---|
NdeI-BamHI fragment from proEx-1/lon cloned into pET24c(+), overexpressed in Escherichia coli Rosetta (DE3) | Homo sapiens |
PCR product cloned into the NcoI and HindIII sites of pET24d(+), overexpressed in Escherichia coli BL21 (DE3) | Salmonella enterica subsp. enterica serovar Typhimurium |
Protein Variants | Comment | Organism |
---|---|---|
V378I | naturally occurring conservative mutation | Salmonella enterica subsp. enterica serovar Typhimurium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cb2-Leu-Leu-Leu | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Cb2-Leu-Leu-Leu-aldehyde | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
isopropylboronic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
MG262 | - |
Homo sapiens | |
MG262 | most potent inhibitor, requires binding, but not hydrolysis, of ATP to initiate inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | epoxomicin, ZL3-VS and ethylboronic acid are ineffective at inhibiting lon at micromolar concentrations | Salmonella enterica subsp. enterica serovar Typhimurium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.046 | - |
ATP | intrinsic ATP hydrolysis | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.15 | - |
ATP | Y(3-NO2)-RGIT2-aminobuytric acid-SGRQ-K(anthranilamide) stimulated ATP hydrolysis | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.172 | - |
ATP | Y(3-NO2)-RGITCySGRQ-K(anthranilamide) stimulated ATP hydrolysis | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.262 | - |
Y(3-NO2)-RGITCSGRQ-K(anthranilamide) | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
0.276 | - |
Y(3-NO2)-RGIT2-aminobuytric acid-SGRQ-K(anthranilamide) | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
1.3 | - |
Y(3-NO2)-RGITCysSGRQ-K(anthranilamide) | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration, to near homogeneity | Homo sapiens |
to near homogeneity | Salmonella enterica subsp. enterica serovar Typhimurium |
Storage Stability | Organism |
---|---|
-80°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | phosphate + ADP | - |
? | |
Y(3-NO2)-RGIT2-aminobutyric acid-SGRQ-K(anthranilamide) + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | Y(3-NO2)-RGIT2-aminobutyrate + SGRQ-K(anthranilamide) | - |
? | |
Y(3-NO2)-RGITCSGRQ-K(anthranilamide) + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | Y(3-NO2)-RGITC + SGRQ-K(anthranilamide) | - |
? | |
Y(3-NO2)-RGITCSGRQ-K(anthranilamide) + H2O | - |
Homo sapiens | Y(3-NO2)-RGITC + SGRQ-K(anthranilamide) | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lon | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
lon | - |
Homo sapiens |
lon protease | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
lon protease | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.41 | - |
ATP | intrinsic ATP hydrolysis | Salmonella enterica subsp. enterica serovar Typhimurium | |
2 | - |
ATP | Y(3-NO2)-RGIT2-aminobuytric acid-SGRQ-K(anthranilamide) stimulated ATP hydrolysis | Salmonella enterica subsp. enterica serovar Typhimurium | |
2 | - |
ATP | Y(3-NO2)-RGITCSGRQ-K(anthranilamide) stimulated ATP hydrolysis | Salmonella enterica subsp. enterica serovar Typhimurium | |
5.9 | - |
Y(3-NO2)-RGITCysSGRQ-K(anthranilamide) | - |
Homo sapiens | |
11 | - |
Y(3-NO2)-RGIT2-aminobuytric acid-SGRQ-K(anthranilamide) | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
15 | - |
Y(3-NO2)-RGITCSGRQ-K(anthranilamide) | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | in the absence of ATP, no peptide cleavage is observed | Salmonella enterica subsp. enterica serovar Typhimurium | |
ATP | in the absence of ATP, no peptide cleavage is observed | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00006 | - |
MG262 | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
0.002 | - |
Cb2-Leu-Leu-Leu-aldehyde | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000122 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | MG262 | |
0.0041 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | Cb2-Leu-Leu-Leu-aldehyde | |
0.74 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | Cb2-Leu-Leu-Leu | |
0.81 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | isopropylboronic acid |