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Literature summary for 3.4.21.53 extracted from

  • Goldberg, A.L.
    The mechanism and functions of ATP-dependent proteases in bacterial and animal cells (1992), Eur. J. Biochem., 203, 9-23.
    View publication on PubMed
Search for more literature for 3.4.21.53

General Stability

General Stability Organism
ATP stabilizes Escherichia coli
glycerol stabilizes Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Escherichia coli
ADP
-
 Rattus norvegicus
diisopropyl fluorophosphate E. coli Escherichia coli
diisopropyl fluorophosphate
-
 Rattus norvegicus
N-ethylmaleimide
-
 Escherichia coli
N-ethylmaleimide
-
 Rattus norvegicus
PMSF
-
 Escherichia coli
PMSF
-
 Rattus norvegicus
vanadate
-
 Escherichia coli
vanadate
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Escherichia coli
Mg2+ requirement Rattus norvegicus
Mg2+ requirement Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
87000
-
 4 * 87000, Escherichia coli
360000
-
 E. coli Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli ATP-dependent serine protease ?
-
 ?
additional information Rattus norvegicus ATP-dependent serine protease ?
-
 ?
Proteins with highly abnormal conformation + H2O Escherichia coli catalyzes inital step in the degradation of proteins with abnormal conformation as may result from nonsense or missense mutations, biosynthetic errors or intracellular denaturation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Escherichia coli
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
hydrolysis of proteins in presence of ATP hydrolysis of proteins in presence of ATP, mechanism Escherichia coli
a
hydrolysis of proteins in presence of ATP hydrolysis of proteins in presence of ATP, mechanism Rattus norvegicus
a
hydrolysis of proteins in presence of ATP hydrolysis of proteins in presence of ATP, mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Bos taurus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Escherichia coli hydrolyzed casein
-
 ?
casein + H2O
-
 Rattus norvegicus hydrolyzed casein
-
 ?
casein + H2O
-
 Bos taurus hydrolyzed casein
-
 ?
Denatured albumin + H2O
-
 Escherichia coli ?
-
 ?
Globin + H2O
-
 Escherichia coli ?
-
 ?
Glutaryl-Ala-Ala-Phe-methoxynaphthylamide + H2O
-
 Escherichia coli Glutaryl-Ala-Ala-Phe + methoxynaphthylamine
-
 ?
additional information ATP-dependent serine protease Escherichia coli ?
-
 ?
additional information ATP-dependent serine protease Rattus norvegicus ?
-
 ?
Proteins with highly abnormal conformation + H2O catalyzes inital step in the degradation of proteins with abnormal conformation as may result from nonsense or missense mutations, biosynthetic errors or intracellular denaturation Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 87000, Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 Escherichia coli Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP requirement Escherichia coli
ATP two ATP molecules are hydrolyzed for each peptide bond cleaved in proteins Escherichia coli
ATP ATP-dependent protease Escherichia coli
ATP ATP-dependent protease Rattus norvegicus
ATP ATP-dependent protease Bos taurus