Literature summary for 3.4.21.5 extracted from

Engh, R.A.; Brandstetter, H.; Sucher, G.; Eichinger, A.; Baumann, U.; Bode, W.; Huber, R.; Poll, T.; Rudolph, R.; von der Saal, W.
Enzyme flexibility, solvent and �weak' interactions characterize thrombin-ligand interactions: implications for drug design (1996), Structure, 4, 1353-1362.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	binding modes of a new class of orally available thrombin inhibitors based on 4-aminopyrimidine. Two inhibitors based on 4-aminopyridine bind in different ways. One forms a water-mediated hydrogen bond to the active site Ser195, the other induces a rotation of the Ser214-Trp215 peptide plane that is unprecedent in thrombin structures	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)