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Literature summary for 3.4.21.5 extracted from

  • Zavyalova, E.G.; Protopopova, A.D.; Yaminsky, I.V.; Kopylov, A.M.
    Kinetic characterization of inhibition of human thrombin with DNA aptamers by turbidimetric assay (2012), Anal. Biochem., 421, 234-239.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
DNA aptamer 15-TBA a thrombin-binding aptamer that binds to thrombin exosites, noncompetitive inhibition type Homo sapiens
DNA aptamer 31-TBA a thrombin-binding aptamer that binds to thrombin exosites, competitive inhibition type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information fibrinogen hydrolysis kinetics, kinetic model, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, overview Homo sapiens