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BRENDA support

Literature summary for 3.4.21.5 extracted from

  • Leoncini, G.; Signorello, M.G.; Segantin, A.; Giacobbe, E.; Armani, U.; Piana, A.; Camicione, P.
    In retinal vein occlusion platelet response to thrombin is increased (2009), Thromb. Res., 124, e48-e55.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

General Information

General Information Comment Organism
physiological function thrombin induces the activation of p38MAPK in human platelets, thrombin increases tyrosine phosphorylation in a concentration-dependent mannerin, resting or in thrombin stimulated platelets total protein tyrosine phosphorylation, p38MAPK, and cytosolic phospholipase A2 phosphorylation are increased Homo sapiens